Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells

Personalized approaches to diagnosis and treatment monitoring could improve the management of cystic fibrosis patients. Here the authors show that multiscale differential dynamic microscopy can assess changes in cilia beating dynamics and coordination in patient-derived airway epithelial cells, in r...

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Autores principales:	M. Chioccioli, L. Feriani, J. Kotar, P. E. Bratcher, P. Cicuta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/edc67efbe3034ef98ada40b3f3a4afc5
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spelling	oai:doaj.org-article:edc67efbe3034ef98ada40b3f3a4afc52021-12-02T14:40:18ZPhenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells10.1038/s41467-019-09798-32041-1723https://doaj.org/article/edc67efbe3034ef98ada40b3f3a4afc52019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09798-3https://doaj.org/toc/2041-1723Personalized approaches to diagnosis and treatment monitoring could improve the management of cystic fibrosis patients. Here the authors show that multiscale differential dynamic microscopy can assess changes in cilia beating dynamics and coordination in patient-derived airway epithelial cells, in response to different CFTR-modulating drugs, in a patient-specific manner.M. ChioccioliL. FerianiJ. KotarP. E. BratcherP. CicutaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Chioccioli L. Feriani J. Kotar P. E. Bratcher P. Cicuta Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
description	Personalized approaches to diagnosis and treatment monitoring could improve the management of cystic fibrosis patients. Here the authors show that multiscale differential dynamic microscopy can assess changes in cilia beating dynamics and coordination in patient-derived airway epithelial cells, in response to different CFTR-modulating drugs, in a patient-specific manner.
format	article
author	M. Chioccioli L. Feriani J. Kotar P. E. Bratcher P. Cicuta
author_facet	M. Chioccioli L. Feriani J. Kotar P. E. Bratcher P. Cicuta
author_sort	M. Chioccioli
title	Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
title_short	Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
title_full	Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
title_fullStr	Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
title_full_unstemmed	Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
title_sort	phenotyping ciliary dynamics and coordination in response to cftr-modulators in cystic fibrosis respiratory epithelial cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/edc67efbe3034ef98ada40b3f3a4afc5
work_keys_str_mv	AT mchioccioli phenotypingciliarydynamicsandcoordinationinresponsetocftrmodulatorsincysticfibrosisrespiratoryepithelialcells AT lferiani phenotypingciliarydynamicsandcoordinationinresponsetocftrmodulatorsincysticfibrosisrespiratoryepithelialcells AT jkotar phenotypingciliarydynamicsandcoordinationinresponsetocftrmodulatorsincysticfibrosisrespiratoryepithelialcells AT pebratcher phenotypingciliarydynamicsandcoordinationinresponsetocftrmodulatorsincysticfibrosisrespiratoryepithelialcells AT pcicuta phenotypingciliarydynamicsandcoordinationinresponsetocftrmodulatorsincysticfibrosisrespiratoryepithelialcells
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Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells

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