A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis

The biosynthesis of the antitumour antibiotic CC-1065 includes formation of a cyclopropane. Here, the authors identify the two enzymes that work together to catalyze this reaction, a radical S-adenosyl-l-methionine enzyme and a methyltransferase, and propose a mechanism for the cyclopropanation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Wen-Bing Jin, Sheng Wu, Xiao-Hong Jian, Hua Yuan, Gong-Li Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/edcd713c52a44ba79dc899e965e8716e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:edcd713c52a44ba79dc899e965e8716e
record_format	dspace
spelling	oai:doaj.org-article:edcd713c52a44ba79dc899e965e8716e2021-12-02T16:50:08ZA radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis10.1038/s41467-018-05217-12041-1723https://doaj.org/article/edcd713c52a44ba79dc899e965e8716e2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05217-1https://doaj.org/toc/2041-1723The biosynthesis of the antitumour antibiotic CC-1065 includes formation of a cyclopropane. Here, the authors identify the two enzymes that work together to catalyze this reaction, a radical S-adenosyl-l-methionine enzyme and a methyltransferase, and propose a mechanism for the cyclopropanation.Wen-Bing JinSheng WuXiao-Hong JianHua YuanGong-Li TangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen-Bing Jin Sheng Wu Xiao-Hong Jian Hua Yuan Gong-Li Tang A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
description	The biosynthesis of the antitumour antibiotic CC-1065 includes formation of a cyclopropane. Here, the authors identify the two enzymes that work together to catalyze this reaction, a radical S-adenosyl-l-methionine enzyme and a methyltransferase, and propose a mechanism for the cyclopropanation.
format	article
author	Wen-Bing Jin Sheng Wu Xiao-Hong Jian Hua Yuan Gong-Li Tang
author_facet	Wen-Bing Jin Sheng Wu Xiao-Hong Jian Hua Yuan Gong-Li Tang
author_sort	Wen-Bing Jin
title	A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
title_short	A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
title_full	A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
title_fullStr	A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
title_full_unstemmed	A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
title_sort	radical s-adenosyl-l-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/edcd713c52a44ba79dc899e965e8716e
work_keys_str_mv	AT wenbingjin aradicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT shengwu aradicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT xiaohongjian aradicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT huayuan aradicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT gonglitang aradicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT wenbingjin radicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT shengwu radicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT xiaohongjian radicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT huayuan radicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis AT gonglitang radicalsadenosyllmethionineenzymeandamethyltransferasecatalyzecyclopropaneformationinnaturalproductbiosynthesis
_version_	1718383131393785856

A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis

Ejemplares similares