In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice

Getu Melesie Taye,1 Mohammed Bule,1 Diriba Alemayehu Gadisa,1 Frehiwot Teka,2 Teferra Abula3 1Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; 2Directorate of Traditional and Modern Medicine Research, Ethiopian Public Health Institute, Addis Ababa, Et...

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Autores principales:	Melesie Taye G, Bule M, Gadisa DA, Teka F, Abula T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetic antidiabetic antihyperglycemic t. schimperi alloxan in vivo. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/edcde5fd82144794bb92096a510ffa97
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spelling	oai:doaj.org-article:edcde5fd82144794bb92096a510ffa972021-12-02T08:20:08ZIn vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice1178-7007https://doaj.org/article/edcde5fd82144794bb92096a510ffa972020-09-01T00:00:00Zhttps://www.dovepress.com/in-vivo-antidiabetic-activity-evaluation-of-aqueous-and-80-methanolic--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Getu Melesie Taye,1 Mohammed Bule,1 Diriba Alemayehu Gadisa,1 Frehiwot Teka,2 Teferra Abula3 1Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; 2Directorate of Traditional and Modern Medicine Research, Ethiopian Public Health Institute, Addis Ababa, Ethiopia; 3Department of Pharmacology, School of Medicine, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Getu Melesie TayeDepartment of Pharmacy, College of Medicine and Health Sciences, Ambo University, PO Box 19, Ambo, EthiopiaEmail getu.melesie@ambou.edu.etIntroduction: Diabetes mellitus disorder characterized by increase in serum glucose level as a result of change in fat, protein metabolism, and carbohydrate. The aim of the present study was to investigate the effects of the aqueous and hydroalcoholic leaf extract of Thymus. schimperi on blood glucose levels.Methods: The aqueous and 80% methanol extracts of T. schimperi leaves were prepared. Swiss albino mice of either sex weighing 20– 30 g were selected for the experiments. Mice that were made diabetic were divided into seven groups to study the antihyperglycemic effect of the extracts. Diabetes was induced by single intraperitonial injection of alloxan monohydrate (180 mg/kg body weight).Results: After diabetic mice were treated with an extract of solvent at doses of 250 and 500 mg/kg for 21 days, there were significant decreases in fasting blood glucose when compared to diabetic controls. The observed antidiabetic activity could be associated with the phytochemicals present in this plant extract. The extract of solvent also prevented body weight loss of diabetic when compared to diabetic mice group. It was also observed that the extracts have shown no acute toxicity at a dose of 2 g/kg.Conclusion: The aqueous and 80% methanol extracts of T. schimperi leaves have shown blood glucose level lowering effects in diabetic mice. Hence, the present study might support the traditional use of T. schimperi for diabetes mellitus treatment.Keywords: diabetic, antidiabetic, alloxan, in vivo, antihyperglycemic, Thymus schimperiMelesie Taye GBule MGadisa DATeka FAbula TDove Medical Pressarticlediabeticantidiabeticantihyperglycemict. schimperialloxanin vivo.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3205-3212 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic antidiabetic antihyperglycemic t. schimperi alloxan in vivo. Specialties of internal medicine RC581-951
spellingShingle	diabetic antidiabetic antihyperglycemic t. schimperi alloxan in vivo. Specialties of internal medicine RC581-951 Melesie Taye G Bule M Gadisa DA Teka F Abula T In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice
description	Getu Melesie Taye,1 Mohammed Bule,1 Diriba Alemayehu Gadisa,1 Frehiwot Teka,2 Teferra Abula3 1Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; 2Directorate of Traditional and Modern Medicine Research, Ethiopian Public Health Institute, Addis Ababa, Ethiopia; 3Department of Pharmacology, School of Medicine, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Getu Melesie TayeDepartment of Pharmacy, College of Medicine and Health Sciences, Ambo University, PO Box 19, Ambo, EthiopiaEmail getu.melesie@ambou.edu.etIntroduction: Diabetes mellitus disorder characterized by increase in serum glucose level as a result of change in fat, protein metabolism, and carbohydrate. The aim of the present study was to investigate the effects of the aqueous and hydroalcoholic leaf extract of Thymus. schimperi on blood glucose levels.Methods: The aqueous and 80% methanol extracts of T. schimperi leaves were prepared. Swiss albino mice of either sex weighing 20– 30 g were selected for the experiments. Mice that were made diabetic were divided into seven groups to study the antihyperglycemic effect of the extracts. Diabetes was induced by single intraperitonial injection of alloxan monohydrate (180 mg/kg body weight).Results: After diabetic mice were treated with an extract of solvent at doses of 250 and 500 mg/kg for 21 days, there were significant decreases in fasting blood glucose when compared to diabetic controls. The observed antidiabetic activity could be associated with the phytochemicals present in this plant extract. The extract of solvent also prevented body weight loss of diabetic when compared to diabetic mice group. It was also observed that the extracts have shown no acute toxicity at a dose of 2 g/kg.Conclusion: The aqueous and 80% methanol extracts of T. schimperi leaves have shown blood glucose level lowering effects in diabetic mice. Hence, the present study might support the traditional use of T. schimperi for diabetes mellitus treatment.Keywords: diabetic, antidiabetic, alloxan, in vivo, antihyperglycemic, Thymus schimperi
format	article
author	Melesie Taye G Bule M Gadisa DA Teka F Abula T
author_facet	Melesie Taye G Bule M Gadisa DA Teka F Abula T
author_sort	Melesie Taye G
title	In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice
title_short	In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice
title_full	In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice
title_fullStr	In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice
title_full_unstemmed	In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice
title_sort	in vivo antidiabetic activity evaluation of aqueous and 80% methanolic extracts of leaves of thymus schimperi (lamiaceae) in alloxan-induced diabetic mice
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/edcde5fd82144794bb92096a510ffa97
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In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of Thymus schimperi (Lamiaceae) in Alloxan-induced Diabetic Mice

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