FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY

The aim of the study was to assess free radical processes and their effect on oxygenation of hemoglobin in the blood of 18-21 weeks pregnant women with exacerbation of cytomegalovirus infection. We examined 40 pregnant women with exacerbation of cytomegalovirus infection and various levels of spe...

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Autores principales:	I. A. Andrievskaya, N. A. Ishutina, O. L. Kutepova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	pregnancy cytomegalovirus infection peripheral blood free radical oxidation hemoglobin oxygenation hemic hypoxia Science Q
Acceso en línea:	https://doaj.org/article/edce9d6136d245fc8fb5d294c383de28
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spelling	oai:doaj.org-article:edce9d6136d245fc8fb5d294c383de282021-11-23T06:14:40ZFREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY2541-94202587-959610.29413/ABS.2018-3.4.1https://doaj.org/article/edce9d6136d245fc8fb5d294c383de282018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/640https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the study was to assess free radical processes and their effect on oxygenation of hemoglobin in the blood of 18-21 weeks pregnant women with exacerbation of cytomegalovirus infection. We examined 40 pregnant women with exacerbation of cytomegalovirus infection and various levels of specific antibodies (IgM) at 18-21 weeks and 30 pregnant women without cytomegalovirus. The spectrophotometric method was used to determine the content of oxyhemoglobin, methemoglobin, thiobarbituric acid (TBA)-active products, superoxide dismutase in blood erythrocytes; thin layer chromatography – phosphotidylcholine, lysophosphatidylcholine; gas-liquid chromatography – arachidonic acid. Exacerbation of cytomegalovirus infection changes the activity of free radical oxidation processes, the severity of which is determined by the level of IgM antibodies and is manifested by a decrease in superoxide dismutase (p = 0.000) and phosphatidylcholine (p = 0.000), an increase in phospholipase A2 (p = 0.000), lysophosphatidylcholine (p = 0.000), arachidonic acid (p = 0.000) and TBA-active products (p = 0.000). Accumulation of superoxide anion radical and products of lipoperoxidation in erythrocytes decreases oxyhemoglobin (p = 0.000) and increases methemoglobin (p = 0.000). Exacerbation of cytomegalovirus infection at 18-21 weeks is associated with the enhancement of free radical lipid oxidation and a deficiency in the antioxidant activity of superoxide dismutase. It decreases oxygen transport properties and increases phagocytosis by red blood monocytes; and pregnant women develop further hemic hypoxia.I. A. AndrievskayaN. A. IshutinaO. L. KutepovaScientific Сentre for Family Health and Human Reproduction Problemsarticlepregnancycytomegalovirus infectionperipheral bloodfree radical oxidationhemoglobin oxygenationhemic hypoxiaScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 9-14 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	pregnancy cytomegalovirus infection peripheral blood free radical oxidation hemoglobin oxygenation hemic hypoxia Science Q
spellingShingle	pregnancy cytomegalovirus infection peripheral blood free radical oxidation hemoglobin oxygenation hemic hypoxia Science Q I. A. Andrievskaya N. A. Ishutina O. L. Kutepova FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY
description	The aim of the study was to assess free radical processes and their effect on oxygenation of hemoglobin in the blood of 18-21 weeks pregnant women with exacerbation of cytomegalovirus infection. We examined 40 pregnant women with exacerbation of cytomegalovirus infection and various levels of specific antibodies (IgM) at 18-21 weeks and 30 pregnant women without cytomegalovirus. The spectrophotometric method was used to determine the content of oxyhemoglobin, methemoglobin, thiobarbituric acid (TBA)-active products, superoxide dismutase in blood erythrocytes; thin layer chromatography – phosphotidylcholine, lysophosphatidylcholine; gas-liquid chromatography – arachidonic acid. Exacerbation of cytomegalovirus infection changes the activity of free radical oxidation processes, the severity of which is determined by the level of IgM antibodies and is manifested by a decrease in superoxide dismutase (p = 0.000) and phosphatidylcholine (p = 0.000), an increase in phospholipase A2 (p = 0.000), lysophosphatidylcholine (p = 0.000), arachidonic acid (p = 0.000) and TBA-active products (p = 0.000). Accumulation of superoxide anion radical and products of lipoperoxidation in erythrocytes decreases oxyhemoglobin (p = 0.000) and increases methemoglobin (p = 0.000). Exacerbation of cytomegalovirus infection at 18-21 weeks is associated with the enhancement of free radical lipid oxidation and a deficiency in the antioxidant activity of superoxide dismutase. It decreases oxygen transport properties and increases phagocytosis by red blood monocytes; and pregnant women develop further hemic hypoxia.
format	article
author	I. A. Andrievskaya N. A. Ishutina O. L. Kutepova
author_facet	I. A. Andrievskaya N. A. Ishutina O. L. Kutepova
author_sort	I. A. Andrievskaya
title	FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY
title_short	FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY
title_full	FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY
title_fullStr	FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY
title_full_unstemmed	FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY
title_sort	free-radical oxidation and oxygenation of hemoglobin at exacerbation of cytomegalovirus infection in the second trimester of pregnancy
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/edce9d6136d245fc8fb5d294c383de28
work_keys_str_mv	AT iaandrievskaya freeradicaloxidationandoxygenationofhemoglobinatexacerbationofcytomegalovirusinfectioninthesecondtrimesterofpregnancy AT naishutina freeradicaloxidationandoxygenationofhemoglobinatexacerbationofcytomegalovirusinfectioninthesecondtrimesterofpregnancy AT olkutepova freeradicaloxidationandoxygenationofhemoglobinatexacerbationofcytomegalovirusinfectioninthesecondtrimesterofpregnancy
_version_	1718416983222910976

FREE-RADICAL OXIDATION AND OXYGENATION OF HEMOGLOBIN AT EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE SECOND TRIMESTER OF PREGNANCY

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