Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial

Background: This randomized controlled trial investigated if uni- and bihemispheric transcranial direct current stimulation (tDCS) of the motor cortex can enhance the effects of visuo-motor grip force tracking task training and transfer to clinical assessments of upper extremity motor function.Metho...

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Autores principales:	Benedikt Taud, Robert Lindenberg, Robert Darkow, Jasmin Wevers, Dorothee Höfflin, Ulrike Grittner, Marcus Meinzer, Agnes Flöel
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chronic stroke tDCS motor function motor rehabilitation hand function Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/edd06ef4a2f84217848de750e512922a
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spelling	oai:doaj.org-article:edd06ef4a2f84217848de750e512922a2021-11-11T04:53:50ZLimited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial1664-229510.3389/fneur.2021.736075https://doaj.org/article/edd06ef4a2f84217848de750e512922a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.736075/fullhttps://doaj.org/toc/1664-2295Background: This randomized controlled trial investigated if uni- and bihemispheric transcranial direct current stimulation (tDCS) of the motor cortex can enhance the effects of visuo-motor grip force tracking task training and transfer to clinical assessments of upper extremity motor function.Methods: In a randomized, double-blind, sham-controlled trial, 40 chronic stroke patients underwent 5 days of visuo-motor grip force tracking task training of the paretic hand with either unilateral or bilateral (N = 15/group) or placebo tDCS (N = 10). Immediate and long-term (3 months) effects on training outcome and motor recovery (Upper Extremity Fugl-Meyer, UE-FM, Wolf Motor Function Test, and WMFT) were investigated.Results: Trained task performance significantly improved independently of tDCS in a curvilinear fashion. In the anodal stimulation group UE-FM scores were higher than in the sham group at day 5 (adjusted mean difference: 2.6, 95%CI: 0.6–4.5, p = 0.010) and at 3 months follow up (adjusted mean difference: 2.8, 95%CI: 0.8–4.7, p = 0.006). Neither training alone, nor the combination of training and tDCS improved WMFT performance.Conclusions: Visuo-motor grip force tracking task training can facilitate recovery of upper extremity function. Only minimal add-on effects of anodal but not dual tDCS were observed.Clinical Trial Registration:https://clinicaltrials.gov/ct2/results?recrs=&cond=&term=NCT01969097&cntry=&state=&city=&dist=, identifier: NCT01969097, retrospectively registered on 25/10/2013.Benedikt TaudRobert LindenbergRobert LindenbergRobert DarkowJasmin WeversDorothee HöfflinUlrike GrittnerUlrike GrittnerMarcus MeinzerMarcus MeinzerAgnes FlöelAgnes FlöelAgnes FlöelAgnes FlöelFrontiers Media S.A.articlechronic stroketDCSmotor functionmotor rehabilitationhand functionNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic stroke tDCS motor function motor rehabilitation hand function Neurology. Diseases of the nervous system RC346-429
spellingShingle	chronic stroke tDCS motor function motor rehabilitation hand function Neurology. Diseases of the nervous system RC346-429 Benedikt Taud Robert Lindenberg Robert Lindenberg Robert Darkow Jasmin Wevers Dorothee Höfflin Ulrike Grittner Ulrike Grittner Marcus Meinzer Marcus Meinzer Agnes Flöel Agnes Flöel Agnes Flöel Agnes Flöel Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial
description	Background: This randomized controlled trial investigated if uni- and bihemispheric transcranial direct current stimulation (tDCS) of the motor cortex can enhance the effects of visuo-motor grip force tracking task training and transfer to clinical assessments of upper extremity motor function.Methods: In a randomized, double-blind, sham-controlled trial, 40 chronic stroke patients underwent 5 days of visuo-motor grip force tracking task training of the paretic hand with either unilateral or bilateral (N = 15/group) or placebo tDCS (N = 10). Immediate and long-term (3 months) effects on training outcome and motor recovery (Upper Extremity Fugl-Meyer, UE-FM, Wolf Motor Function Test, and WMFT) were investigated.Results: Trained task performance significantly improved independently of tDCS in a curvilinear fashion. In the anodal stimulation group UE-FM scores were higher than in the sham group at day 5 (adjusted mean difference: 2.6, 95%CI: 0.6–4.5, p = 0.010) and at 3 months follow up (adjusted mean difference: 2.8, 95%CI: 0.8–4.7, p = 0.006). Neither training alone, nor the combination of training and tDCS improved WMFT performance.Conclusions: Visuo-motor grip force tracking task training can facilitate recovery of upper extremity function. Only minimal add-on effects of anodal but not dual tDCS were observed.Clinical Trial Registration:https://clinicaltrials.gov/ct2/results?recrs=&cond=&term=NCT01969097&cntry=&state=&city=&dist=, identifier: NCT01969097, retrospectively registered on 25/10/2013.
format	article
author	Benedikt Taud Robert Lindenberg Robert Lindenberg Robert Darkow Jasmin Wevers Dorothee Höfflin Ulrike Grittner Ulrike Grittner Marcus Meinzer Marcus Meinzer Agnes Flöel Agnes Flöel Agnes Flöel Agnes Flöel
author_facet	Benedikt Taud Robert Lindenberg Robert Lindenberg Robert Darkow Jasmin Wevers Dorothee Höfflin Ulrike Grittner Ulrike Grittner Marcus Meinzer Marcus Meinzer Agnes Flöel Agnes Flöel Agnes Flöel Agnes Flöel
author_sort	Benedikt Taud
title	Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial
title_short	Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial
title_full	Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial
title_fullStr	Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial
title_full_unstemmed	Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial
title_sort	limited add-on effects of unilateral and bilateral transcranial direct current stimulation on visuo-motor grip force tracking task training outcome in chronic stroke. a randomized controlled trial
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/edd06ef4a2f84217848de750e512922a
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Limited Add-On Effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Visuo-Motor Grip Force Tracking Task Training Outcome in Chronic Stroke. A Randomized Controlled Trial

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