Effects of long-term hydrogen intervention on the physiological function of rats

Abstract The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (...

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Autores principales:	Zhi-ming Xun, Qing-hui Zhao, Yan Zhang, Fang-di Ju, Jin He, Ting-ting Yao, Xiao-kang Zhang, Yang Yi, Sheng-nan Ma, Peng-xiang Zhao, Xiao-yan Jin, Ying-xian Li, Xiao-yang Li, Xue-mei Ma, Fei Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edd38d7b47c344379904e272a24308dc
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spelling	oai:doaj.org-article:edd38d7b47c344379904e272a24308dc2021-12-02T15:09:22ZEffects of long-term hydrogen intervention on the physiological function of rats10.1038/s41598-020-75492-w2045-2322https://doaj.org/article/edd38d7b47c344379904e272a24308dc2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-75492-whttps://doaj.org/toc/2045-2322Abstract The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW intake and HI remains elusive. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. Among the 13 parameters, the most striking alterations induced by hydrogen treatment were observed in serum myocardial enzymes spectrum. The results also showed that the changes in these parameters occurred at different time points, and the alterations in most of the parameters were much more significant in HI than HRW. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future.Zhi-ming XunQing-hui ZhaoYan ZhangFang-di JuJin HeTing-ting YaoXiao-kang ZhangYang YiSheng-nan MaPeng-xiang ZhaoXiao-yan JinYing-xian LiXiao-yang LiXue-mei MaFei XieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhi-ming Xun Qing-hui Zhao Yan Zhang Fang-di Ju Jin He Ting-ting Yao Xiao-kang Zhang Yang Yi Sheng-nan Ma Peng-xiang Zhao Xiao-yan Jin Ying-xian Li Xiao-yang Li Xue-mei Ma Fei Xie Effects of long-term hydrogen intervention on the physiological function of rats
description	Abstract The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW intake and HI remains elusive. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. Among the 13 parameters, the most striking alterations induced by hydrogen treatment were observed in serum myocardial enzymes spectrum. The results also showed that the changes in these parameters occurred at different time points, and the alterations in most of the parameters were much more significant in HI than HRW. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future.
format	article
author	Zhi-ming Xun Qing-hui Zhao Yan Zhang Fang-di Ju Jin He Ting-ting Yao Xiao-kang Zhang Yang Yi Sheng-nan Ma Peng-xiang Zhao Xiao-yan Jin Ying-xian Li Xiao-yang Li Xue-mei Ma Fei Xie
author_facet	Zhi-ming Xun Qing-hui Zhao Yan Zhang Fang-di Ju Jin He Ting-ting Yao Xiao-kang Zhang Yang Yi Sheng-nan Ma Peng-xiang Zhao Xiao-yan Jin Ying-xian Li Xiao-yang Li Xue-mei Ma Fei Xie
author_sort	Zhi-ming Xun
title	Effects of long-term hydrogen intervention on the physiological function of rats
title_short	Effects of long-term hydrogen intervention on the physiological function of rats
title_full	Effects of long-term hydrogen intervention on the physiological function of rats
title_fullStr	Effects of long-term hydrogen intervention on the physiological function of rats
title_full_unstemmed	Effects of long-term hydrogen intervention on the physiological function of rats
title_sort	effects of long-term hydrogen intervention on the physiological function of rats
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/edd38d7b47c344379904e272a24308dc
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Effects of long-term hydrogen intervention on the physiological function of rats

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