Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model

Valosin-containing protein (VCP) was found to play a vital protective role against cardiac stresses. Genetic mutations of VCP are associated with human dilated cardiomyopathy. However, the essential role of VCP in the heart during the physiological condition remains unknown since the VCP knockout in...

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Autores principales:	Xiaonan Sun, Ning Zhou, Ben Ma, Wenqian Wu, Shaunrick Stoll, Lo Lai, Gangjian Qin, Hongyu Qiu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	valosin-containing protein dilated cardiomyopathy nuclear translocation co-factor interaction P47 nuclear protein localization protein 4 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/edd7597b2f3f4e32b0397aa06d10e564
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Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model

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