Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland

Abstract Listeria monocytogenes is an opportunistic pathogen that is widely distributed in the environment. The aquatic environment may represent a potential source for the transmission of L. monocytogenes to animals and the food chain. The present study assessed the occurrence of L. monocytogenes i...

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Autores principales:	Susanne Raschle, Roger Stephan, Marc J. A. Stevens, Nicole Cernela, Katrin Zurfluh, Francis Muchaamba, Magdalena Nüesch-Inderbinen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edd7f122523f4b4999a486bace00a3b5
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spelling	oai:doaj.org-article:edd7f122523f4b4999a486bace00a3b52021-12-02T17:39:20ZEnvironmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland10.1038/s41598-021-88514-y2045-2322https://doaj.org/article/edd7f122523f4b4999a486bace00a3b52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88514-yhttps://doaj.org/toc/2045-2322Abstract Listeria monocytogenes is an opportunistic pathogen that is widely distributed in the environment. The aquatic environment may represent a potential source for the transmission of L. monocytogenes to animals and the food chain. The present study assessed the occurrence of L. monocytogenes in 191 surface water samples from rivers, streams and inland canals throughout Switzerland. Twenty-five (13%) of the surface water samples contained L. monocytogenes. Whole genome sequence (WGS) data were used to characterize the 25 isolates. The isolates belonged to major lineages I and II, with the majority assigned to either serotype 1/2a (48%), or 4b (44%). The predominant CCs identified were the hypervirulent serotype 4b clones CC1 and CC4, and the serotype CC412; all three have been implicated in listeriosis outbreaks and sporadic cases of human and animal infection worldwide. Two (8%) of the isolates belonged to CC6 which is an emerging hypervirulent clone. All isolates contained intact genes associated with invasion and infection, including inlA/B and prfA. The four CC4 isolates all harbored Listeria pathogenicity island 4 (LIPI-4), which confers hypervirulence. The occurrence of L. monocytogenes in river ecosystems may contribute to the dissemination and introduction of clinically highly relevant strains to the food chain.Susanne RaschleRoger StephanMarc J. A. StevensNicole CernelaKatrin ZurfluhFrancis MuchaambaMagdalena Nüesch-InderbinenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susanne Raschle Roger Stephan Marc J. A. Stevens Nicole Cernela Katrin Zurfluh Francis Muchaamba Magdalena Nüesch-Inderbinen Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland
description	Abstract Listeria monocytogenes is an opportunistic pathogen that is widely distributed in the environment. The aquatic environment may represent a potential source for the transmission of L. monocytogenes to animals and the food chain. The present study assessed the occurrence of L. monocytogenes in 191 surface water samples from rivers, streams and inland canals throughout Switzerland. Twenty-five (13%) of the surface water samples contained L. monocytogenes. Whole genome sequence (WGS) data were used to characterize the 25 isolates. The isolates belonged to major lineages I and II, with the majority assigned to either serotype 1/2a (48%), or 4b (44%). The predominant CCs identified were the hypervirulent serotype 4b clones CC1 and CC4, and the serotype CC412; all three have been implicated in listeriosis outbreaks and sporadic cases of human and animal infection worldwide. Two (8%) of the isolates belonged to CC6 which is an emerging hypervirulent clone. All isolates contained intact genes associated with invasion and infection, including inlA/B and prfA. The four CC4 isolates all harbored Listeria pathogenicity island 4 (LIPI-4), which confers hypervirulence. The occurrence of L. monocytogenes in river ecosystems may contribute to the dissemination and introduction of clinically highly relevant strains to the food chain.
format	article
author	Susanne Raschle Roger Stephan Marc J. A. Stevens Nicole Cernela Katrin Zurfluh Francis Muchaamba Magdalena Nüesch-Inderbinen
author_facet	Susanne Raschle Roger Stephan Marc J. A. Stevens Nicole Cernela Katrin Zurfluh Francis Muchaamba Magdalena Nüesch-Inderbinen
author_sort	Susanne Raschle
title	Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland
title_short	Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland
title_full	Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland
title_fullStr	Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland
title_full_unstemmed	Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland
title_sort	environmental dissemination of pathogenic listeria monocytogenes in flowing surface waters in switzerland
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edd7f122523f4b4999a486bace00a3b5
work_keys_str_mv	AT susanneraschle environmentaldisseminationofpathogeniclisteriamonocytogenesinflowingsurfacewatersinswitzerland AT rogerstephan environmentaldisseminationofpathogeniclisteriamonocytogenesinflowingsurfacewatersinswitzerland AT marcjastevens environmentaldisseminationofpathogeniclisteriamonocytogenesinflowingsurfacewatersinswitzerland AT nicolecernela environmentaldisseminationofpathogeniclisteriamonocytogenesinflowingsurfacewatersinswitzerland AT katrinzurfluh environmentaldisseminationofpathogeniclisteriamonocytogenesinflowingsurfacewatersinswitzerland AT francismuchaamba environmentaldisseminationofpathogeniclisteriamonocytogenesinflowingsurfacewatersinswitzerland AT magdalenanueschinderbinen environmentaldisseminationofpathogeniclisteriamonocytogenesinflowingsurfacewatersinswitzerland
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Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland

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