Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments

Abstract The vestibular receptor of cupula acts an important role in maintaining body balance. However, the cupula buried in the semicircular canals (SCCs) will be destroyed if it is detached from the relevant environment. The mechanical properties of human cupula still remain ambiguous. In this pap...

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Autores principales:	Xiang Wu, Shen Yu, Shuang Shen, Wenlong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edd8727ea32249d7bbf6da3fa2898376
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spelling	oai:doaj.org-article:edd8727ea32249d7bbf6da3fa28983762021-12-02T14:26:12ZExploring the biomechanical responses of human cupula by numerical analysis of temperature experiments10.1038/s41598-021-87730-w2045-2322https://doaj.org/article/edd8727ea32249d7bbf6da3fa28983762021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87730-whttps://doaj.org/toc/2045-2322Abstract The vestibular receptor of cupula acts an important role in maintaining body balance. However, the cupula buried in the semicircular canals (SCCs) will be destroyed if it is detached from the relevant environment. The mechanical properties of human cupula still remain ambiguous. In this paper, we explored the cupula responses changing with temperature by experiments and numerical simulation of SCCs model. We obtained 3 volunteers’ nystagmus induced by constant angular acceleration when the temperature of volunteers’ SCCs was 36 °C and 37 °C respectively. The slow-phase velocity of 3 volunteers decreased by approximately 3°/s when the temperature of SCCs reduced by 1 °C, which corresponded to the reduction of cupula deformation by 0.3–0.8 μm in the numerical model. Furthermore, we investigated the effects of the variation of endolymphatic properties induced by temperature reduction on cupula deformation through numerical simulation. We found that the decrease of cupula deformation was not caused by the change of endolymphatic properties, but probably by the increase of cupula’s elastic modulus. With the temperature reducing by 1 °C, the cupula’s elastic modulus may increase by 6–20%, suggesting that the stiffness of cupula is enhanced. This exploration of temperature characteristic of human cupula promotes the research of alleviating vestibular diseases.Xiang WuShen YuShuang ShenWenlong LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiang Wu Shen Yu Shuang Shen Wenlong Liu Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments
description	Abstract The vestibular receptor of cupula acts an important role in maintaining body balance. However, the cupula buried in the semicircular canals (SCCs) will be destroyed if it is detached from the relevant environment. The mechanical properties of human cupula still remain ambiguous. In this paper, we explored the cupula responses changing with temperature by experiments and numerical simulation of SCCs model. We obtained 3 volunteers’ nystagmus induced by constant angular acceleration when the temperature of volunteers’ SCCs was 36 °C and 37 °C respectively. The slow-phase velocity of 3 volunteers decreased by approximately 3°/s when the temperature of SCCs reduced by 1 °C, which corresponded to the reduction of cupula deformation by 0.3–0.8 μm in the numerical model. Furthermore, we investigated the effects of the variation of endolymphatic properties induced by temperature reduction on cupula deformation through numerical simulation. We found that the decrease of cupula deformation was not caused by the change of endolymphatic properties, but probably by the increase of cupula’s elastic modulus. With the temperature reducing by 1 °C, the cupula’s elastic modulus may increase by 6–20%, suggesting that the stiffness of cupula is enhanced. This exploration of temperature characteristic of human cupula promotes the research of alleviating vestibular diseases.
format	article
author	Xiang Wu Shen Yu Shuang Shen Wenlong Liu
author_facet	Xiang Wu Shen Yu Shuang Shen Wenlong Liu
author_sort	Xiang Wu
title	Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments
title_short	Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments
title_full	Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments
title_fullStr	Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments
title_full_unstemmed	Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments
title_sort	exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edd8727ea32249d7bbf6da3fa2898376
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Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments

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