Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae

Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap endonuclease activity catalyzes mispair excision.

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Autores principales:	Felipe A. Calil, Bin-Zhong Li, Kendall A. Torres, Katarina Nguyen, Nikki Bowen, Christopher D. Putnam, Richard D. Kolodner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/edd8c42e20fe4ec2a4fcf1e024649b17
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spelling	oai:doaj.org-article:edd8c42e20fe4ec2a4fcf1e024649b172021-12-02T18:48:25ZRad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae10.1038/s41467-021-25866-z2041-1723https://doaj.org/article/edd8c42e20fe4ec2a4fcf1e024649b172021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25866-zhttps://doaj.org/toc/2041-1723Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap endonuclease activity catalyzes mispair excision.Felipe A. CalilBin-Zhong LiKendall A. TorresKatarina NguyenNikki BowenChristopher D. PutnamRichard D. KolodnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Felipe A. Calil Bin-Zhong Li Kendall A. Torres Katarina Nguyen Nikki Bowen Christopher D. Putnam Richard D. Kolodner Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae
description	Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap endonuclease activity catalyzes mispair excision.
format	article
author	Felipe A. Calil Bin-Zhong Li Kendall A. Torres Katarina Nguyen Nikki Bowen Christopher D. Putnam Richard D. Kolodner
author_facet	Felipe A. Calil Bin-Zhong Li Kendall A. Torres Katarina Nguyen Nikki Bowen Christopher D. Putnam Richard D. Kolodner
author_sort	Felipe A. Calil
title	Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae
title_short	Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae
title_full	Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae
title_fullStr	Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae
title_full_unstemmed	Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae
title_sort	rad27 and exo1 function in different excision pathways for mismatch repair in saccharomyces cerevisiae
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edd8c42e20fe4ec2a4fcf1e024649b17
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Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae

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