NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

The authors use an integrative clustering approach to identify two laryngeal cancer clusters with distinct prognosis and show that mutations damaging the NSD1 and NSD2 methyltransferases segregate to the cluster with favorable prognosis, and independently predict longer survival in patients with lar...

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Autores principales:	Suraj Peri, Evgeny Izumchenko, Adrian D. Schubert, Michael J. Slifker, Karen Ruth, Ilya G. Serebriiskii, Theresa Guo, Barbara A. Burtness, Ranee Mehra, Eric A. Ross, David Sidransky, Erica A. Golemis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eddde834c4f34581ae63259cb1d66acc
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spelling	oai:doaj.org-article:eddde834c4f34581ae63259cb1d66acc2021-12-02T14:42:07ZNSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis10.1038/s41467-017-01877-72041-1723https://doaj.org/article/eddde834c4f34581ae63259cb1d66acc2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01877-7https://doaj.org/toc/2041-1723The authors use an integrative clustering approach to identify two laryngeal cancer clusters with distinct prognosis and show that mutations damaging the NSD1 and NSD2 methyltransferases segregate to the cluster with favorable prognosis, and independently predict longer survival in patients with laryngeal, but not other head and neck cancers.Suraj PeriEvgeny IzumchenkoAdrian D. SchubertMichael J. SlifkerKaren RuthIlya G. SerebriiskiiTheresa GuoBarbara A. BurtnessRanee MehraEric A. RossDavid SidranskyErica A. GolemisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Suraj Peri Evgeny Izumchenko Adrian D. Schubert Michael J. Slifker Karen Ruth Ilya G. Serebriiskii Theresa Guo Barbara A. Burtness Ranee Mehra Eric A. Ross David Sidransky Erica A. Golemis NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
description	The authors use an integrative clustering approach to identify two laryngeal cancer clusters with distinct prognosis and show that mutations damaging the NSD1 and NSD2 methyltransferases segregate to the cluster with favorable prognosis, and independently predict longer survival in patients with laryngeal, but not other head and neck cancers.
format	article
author	Suraj Peri Evgeny Izumchenko Adrian D. Schubert Michael J. Slifker Karen Ruth Ilya G. Serebriiskii Theresa Guo Barbara A. Burtness Ranee Mehra Eric A. Ross David Sidransky Erica A. Golemis
author_facet	Suraj Peri Evgeny Izumchenko Adrian D. Schubert Michael J. Slifker Karen Ruth Ilya G. Serebriiskii Theresa Guo Barbara A. Burtness Ranee Mehra Eric A. Ross David Sidransky Erica A. Golemis
author_sort	Suraj Peri
title	NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
title_short	NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
title_full	NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
title_fullStr	NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
title_full_unstemmed	NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
title_sort	nsd1- and nsd2-damaging mutations define a subset of laryngeal tumors with favorable prognosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eddde834c4f34581ae63259cb1d66acc
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NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

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