Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials

Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials

Jørn Ditzel, Hans Henrik LervangDepartment of Endocrinology, and Center for Prevention of Struma and Metabolic Diseases, Aalborg University Hospital, Aarhus University, DenmarkAbstract: A paradoxical metabolic imbalance in inorganic phosphate occurs from the early onset of diabetes an...

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Autores principales: Jørn Ditzel, Hans Henrik Lervang
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2009
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Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/edde048fab82445dbf8388cf85af09da
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spelling oai:doaj.org-article:edde048fab82445dbf8388cf85af09da2021-12-02T01:36:07ZDisturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials1178-7007https://doaj.org/article/edde048fab82445dbf8388cf85af09da2009-10-01T00:00:00Zhttp://www.dovepress.com/disturbance-of-inorganic-phosphate-metabolism-in-diabetes-mellitus-tem-a3613https://doaj.org/toc/1178-7007Jørn Ditzel, Hans Henrik LervangDepartment of Endocrinology, and Center for Prevention of Struma and Metabolic Diseases, Aalborg University Hospital, Aarhus University, DenmarkAbstract: A paradoxical metabolic imbalance in inorganic phosphate occurs from the early onset of diabetes and may lead to a reduction of high energy phosphates and tissue hypoxia. These changes take place in the cells and tissues in which the entry of glucose is not controlled by insulin, and particularly in poorly regulated diabetes patients in whom long-term vascular complications are more likely to occur. Several therapeutic intervention trials have been carried out, including assessment of optimal glucose regulation, the effect of dietary inclusion of calcium diphosphate and pharmaceutical intake of etidronate disodium (EHDP), but none of these modalities wholly overcome the problem. The potential therapeutic application of fructose-1, 6-diphosphate, however, which also acts as human bioenergy, holds a great deal of promise as an efficacious and well-tolerated therapeutic regimen.Keywords: diabetes, inorganic phosphate metabolism, early intervention trials Jørn DitzelHans Henrik LervangDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2009, Iss default, Pp 173-177 (2009)
institution DOAJ
collection DOAJ
language EN
topic Specialties of internal medicine
RC581-951
spellingShingle Specialties of internal medicine
RC581-951
Jørn Ditzel
Hans Henrik Lervang
Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials
description Jørn Ditzel, Hans Henrik LervangDepartment of Endocrinology, and Center for Prevention of Struma and Metabolic Diseases, Aalborg University Hospital, Aarhus University, DenmarkAbstract: A paradoxical metabolic imbalance in inorganic phosphate occurs from the early onset of diabetes and may lead to a reduction of high energy phosphates and tissue hypoxia. These changes take place in the cells and tissues in which the entry of glucose is not controlled by insulin, and particularly in poorly regulated diabetes patients in whom long-term vascular complications are more likely to occur. Several therapeutic intervention trials have been carried out, including assessment of optimal glucose regulation, the effect of dietary inclusion of calcium diphosphate and pharmaceutical intake of etidronate disodium (EHDP), but none of these modalities wholly overcome the problem. The potential therapeutic application of fructose-1, 6-diphosphate, however, which also acts as human bioenergy, holds a great deal of promise as an efficacious and well-tolerated therapeutic regimen.Keywords: diabetes, inorganic phosphate metabolism, early intervention trials
format article
author Jørn Ditzel
Hans Henrik Lervang
author_facet Jørn Ditzel
Hans Henrik Lervang
author_sort Jørn Ditzel
title Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials
title_short Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials
title_full Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials
title_fullStr Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials
title_full_unstemmed Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials
title_sort disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials
publisher Dove Medical Press
publishDate 2009
url https://doaj.org/article/edde048fab82445dbf8388cf85af09da
work_keys_str_mv AT jamposlashrnditzel disturbanceofinorganicphosphatemetabolismindiabetesmellitustemporarytherapeuticinterventiontrials
AT hanshenriklervang disturbanceofinorganicphosphatemetabolismindiabetesmellitustemporarytherapeuticinterventiontrials
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