Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

FXR plays an important role in bile acid homeostasis by transcriptionally modulating several enterohepatic genes, including intestinal FGF19, that repress hepatic bile acid synthesis. Here the authors show that postprandial FGF19 regulates FXR transcriptional activity via its action on the tyrosine...

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Auteurs principaux:	Sangwon Byun, Dong-Hyun Kim, Daniel Ryerson, Young-Chae Kim, Hao Sun, Bo Kong, Peter Yau, Grace Guo, H. Eric Xu, Byron Kemper, Jongsook Kim Kemper
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ede05f8dfd03477aa0bea239f68b13ab
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id	oai:doaj.org-article:ede05f8dfd03477aa0bea239f68b13ab
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spelling	oai:doaj.org-article:ede05f8dfd03477aa0bea239f68b13ab2021-12-02T14:40:43ZPostprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis10.1038/s41467-018-04697-52041-1723https://doaj.org/article/ede05f8dfd03477aa0bea239f68b13ab2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04697-5https://doaj.org/toc/2041-1723FXR plays an important role in bile acid homeostasis by transcriptionally modulating several enterohepatic genes, including intestinal FGF19, that repress hepatic bile acid synthesis. Here the authors show that postprandial FGF19 regulates FXR transcriptional activity via its action on the tyrosine kinase Src, which phosphorylates FXR.Sangwon ByunDong-Hyun KimDaniel RyersonYoung-Chae KimHao SunBo KongPeter YauGrace GuoH. Eric XuByron KemperJongsook Kim KemperNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sangwon Byun Dong-Hyun Kim Daniel Ryerson Young-Chae Kim Hao Sun Bo Kong Peter Yau Grace Guo H. Eric Xu Byron Kemper Jongsook Kim Kemper Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
description	FXR plays an important role in bile acid homeostasis by transcriptionally modulating several enterohepatic genes, including intestinal FGF19, that repress hepatic bile acid synthesis. Here the authors show that postprandial FGF19 regulates FXR transcriptional activity via its action on the tyrosine kinase Src, which phosphorylates FXR.
format	article
author	Sangwon Byun Dong-Hyun Kim Daniel Ryerson Young-Chae Kim Hao Sun Bo Kong Peter Yau Grace Guo H. Eric Xu Byron Kemper Jongsook Kim Kemper
author_facet	Sangwon Byun Dong-Hyun Kim Daniel Ryerson Young-Chae Kim Hao Sun Bo Kong Peter Yau Grace Guo H. Eric Xu Byron Kemper Jongsook Kim Kemper
author_sort	Sangwon Byun
title	Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
title_short	Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
title_full	Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
title_fullStr	Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
title_full_unstemmed	Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
title_sort	postprandial fgf19-induced phosphorylation by src is critical for fxr function in bile acid homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ede05f8dfd03477aa0bea239f68b13ab
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Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

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