Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show that constitutive nutrient signaling regulates...

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Autores principales:	Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ede1c5d31c18497daed3a08d29f4a91b
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spelling	oai:doaj.org-article:ede1c5d31c18497daed3a08d29f4a91b2021-12-02T17:40:28ZLimited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling10.1038/s41467-021-23857-82041-1723https://doaj.org/article/ede1c5d31c18497daed3a08d29f4a91b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23857-8https://doaj.org/toc/2041-1723The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show that constitutive nutrient signaling regulates the response to feeding-fasting cycles and does not drive liver cancer.Celia de la Calle ArreguiAna Belén Plata-GómezNerea Deleyto-SeldasFernando GarcíaAna Ortega-MolinaJulio Abril-GarridoElena RodriguezIvan NemazanyyLaura TribouillardAlba de MartinoEduardo CaleirasRamón Campos-OlivasFrancisca MuleroMathieu LaplanteJavier MuñozMario PendeGuadalupe SabioDavid M. SabatiniAlejo EfeyanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Celia de la Calle Arregui Ana Belén Plata-Gómez Nerea Deleyto-Seldas Fernando García Ana Ortega-Molina Julio Abril-Garrido Elena Rodriguez Ivan Nemazanyy Laura Tribouillard Alba de Martino Eduardo Caleiras Ramón Campos-Olivas Francisca Mulero Mathieu Laplante Javier Muñoz Mario Pende Guadalupe Sabio David M. Sabatini Alejo Efeyan Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
description	The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show that constitutive nutrient signaling regulates the response to feeding-fasting cycles and does not drive liver cancer.
format	article
author	Celia de la Calle Arregui Ana Belén Plata-Gómez Nerea Deleyto-Seldas Fernando García Ana Ortega-Molina Julio Abril-Garrido Elena Rodriguez Ivan Nemazanyy Laura Tribouillard Alba de Martino Eduardo Caleiras Ramón Campos-Olivas Francisca Mulero Mathieu Laplante Javier Muñoz Mario Pende Guadalupe Sabio David M. Sabatini Alejo Efeyan
author_facet	Celia de la Calle Arregui Ana Belén Plata-Gómez Nerea Deleyto-Seldas Fernando García Ana Ortega-Molina Julio Abril-Garrido Elena Rodriguez Ivan Nemazanyy Laura Tribouillard Alba de Martino Eduardo Caleiras Ramón Campos-Olivas Francisca Mulero Mathieu Laplante Javier Muñoz Mario Pende Guadalupe Sabio David M. Sabatini Alejo Efeyan
author_sort	Celia de la Calle Arregui
title	Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
title_short	Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
title_full	Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
title_fullStr	Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
title_full_unstemmed	Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
title_sort	limited survival and impaired hepatic fasting metabolism in mice with constitutive rag gtpase signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ede1c5d31c18497daed3a08d29f4a91b
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Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

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