Neuromolecular Underpinnings of Negative Cognitive Bias in Depression

This selective review aims to summarize the recent advances in understanding the neuromolecular underpinnings of biased cognition in depressive disorder. We begin by considering the cognitive correlates of depressed mood and the key brain systems implicated in its development. We then review the cor...

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Autores principales:	Karolina Noworyta, Agata Cieslik, Rafal Rygula
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	depression cognitive dopamine serotonin noradrenaline judgment bias Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ede2d68c4117443faa32e95e2e0a1401
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spelling	oai:doaj.org-article:ede2d68c4117443faa32e95e2e0a14012021-11-25T17:12:06ZNeuromolecular Underpinnings of Negative Cognitive Bias in Depression10.3390/cells101131572073-4409https://doaj.org/article/ede2d68c4117443faa32e95e2e0a14012021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3157https://doaj.org/toc/2073-4409This selective review aims to summarize the recent advances in understanding the neuromolecular underpinnings of biased cognition in depressive disorder. We begin by considering the cognitive correlates of depressed mood and the key brain systems implicated in its development. We then review the core findings across two domains of biased cognitive function in depression: pessimistic judgment bias and abnormal response to negative feedback. In considering their underlying substrates, we focus on the neurochemical mechanisms identified by genetic, molecular and pharmacological challenge studies. We conclude by discussing experimental approaches to the treatment of depression, which are derived largely from an improved understanding of its cognitive substrates.Karolina NoworytaAgata CieslikRafal RygulaMDPI AGarticledepressioncognitivedopamineserotoninnoradrenalinejudgment biasBiology (General)QH301-705.5ENCells, Vol 10, Iss 3157, p 3157 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression cognitive dopamine serotonin noradrenaline judgment bias Biology (General) QH301-705.5
spellingShingle	depression cognitive dopamine serotonin noradrenaline judgment bias Biology (General) QH301-705.5 Karolina Noworyta Agata Cieslik Rafal Rygula Neuromolecular Underpinnings of Negative Cognitive Bias in Depression
description	This selective review aims to summarize the recent advances in understanding the neuromolecular underpinnings of biased cognition in depressive disorder. We begin by considering the cognitive correlates of depressed mood and the key brain systems implicated in its development. We then review the core findings across two domains of biased cognitive function in depression: pessimistic judgment bias and abnormal response to negative feedback. In considering their underlying substrates, we focus on the neurochemical mechanisms identified by genetic, molecular and pharmacological challenge studies. We conclude by discussing experimental approaches to the treatment of depression, which are derived largely from an improved understanding of its cognitive substrates.
format	article
author	Karolina Noworyta Agata Cieslik Rafal Rygula
author_facet	Karolina Noworyta Agata Cieslik Rafal Rygula
author_sort	Karolina Noworyta
title	Neuromolecular Underpinnings of Negative Cognitive Bias in Depression
title_short	Neuromolecular Underpinnings of Negative Cognitive Bias in Depression
title_full	Neuromolecular Underpinnings of Negative Cognitive Bias in Depression
title_fullStr	Neuromolecular Underpinnings of Negative Cognitive Bias in Depression
title_full_unstemmed	Neuromolecular Underpinnings of Negative Cognitive Bias in Depression
title_sort	neuromolecular underpinnings of negative cognitive bias in depression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ede2d68c4117443faa32e95e2e0a1401
work_keys_str_mv	AT karolinanoworyta neuromolecularunderpinningsofnegativecognitivebiasindepression AT agatacieslik neuromolecularunderpinningsofnegativecognitivebiasindepression AT rafalrygula neuromolecularunderpinningsofnegativecognitivebiasindepression
_version_	1718412686792851456

Neuromolecular Underpinnings of Negative Cognitive Bias in Depression

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