ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS

Emergence and development of pulmonary tuberculosis is often accompanied by the signs of immune system dysfunction. The key enzymes of purine metabolism, e.g., adenosine deaminase (ADA and its isoforms, i.e. ADA1, ADA1 protein complex, and ADA-2), ecto-5’-nucleotidase (5’-NC) controlling adenosine l...

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Autores principales:	M. Ye. Dyakova, V. Yu. Zhuravlev, D. S. Esmedlyaeva, T. L. Perova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	tuberculosis adenosine deaminase ecto-5’-nucleotidase cd26 cytokines mononuclear cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ede457f9020c4ef6987dc344cc8ca773
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spelling	oai:doaj.org-article:ede457f9020c4ef6987dc344cc8ca7732021-11-18T08:03:45ZROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2016-1-85-90https://doaj.org/article/ede457f9020c4ef6987dc344cc8ca7732016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/991https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XEmergence and development of pulmonary tuberculosis is often accompanied by the signs of immune system dysfunction. The key enzymes of purine metabolism, e.g., adenosine deaminase (ADA and its isoforms, i.e. ADA1, ADA1 protein complex, and ADA-2), ecto-5’-nucleotidase (5’-NC) controlling adenosine levels, may play an important role in regulation of cell-mediated immunity. We have correlated the parameters of purine metabolism with cytokine production in patients with fibro-cavernous pulmonary tuberculosis (FCT) with a severe specific process. Our studies have revealed an association between cytokine production and purine metabolism indexes, thus reflecting an important role of the latters in immunopathogenesis of the hyperchronic specific disorder. It is mainly referred to adenosine deaminase (ADA1 and ADA2) which are antagonistic in regulation of IL-17 and IL-18. A significantly decreased activity of intracellular ADA1, lowered CD26 concentrations, with lacking intercorrelation, along with increased activity of ecto-ADA-2 is, generally, typical to patients with fibrous-cavernous tuberculosis, thus being a possible marker for prediction of unfavorable hyperchronic specific process, being consistent with functional depletion of immunocompetent cells. Lack of the ADA/ectopeptidase complexes leads to an imbalance between adenosine supply and its deamination. Increased extracellular adenosine concentrations in the patients with severe specific processes may cause metabolic alterations of immunocompetent cells, thus complicating clinical course of the disease, e.g., contributing to enhancement and progression of pulmonary fibrosis.M. Ye. DyakovaV. Yu. ZhuravlevD. S. EsmedlyaevaT. L. PerovaSPb RAACIarticletuberculosisadenosine deaminaseecto-5’-nucleotidasecd26cytokinesmononuclear cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 1, Pp 85-90 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis adenosine deaminase ecto-5’-nucleotidase cd26 cytokines mononuclear cells Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis adenosine deaminase ecto-5’-nucleotidase cd26 cytokines mononuclear cells Immunologic diseases. Allergy RC581-607 M. Ye. Dyakova V. Yu. Zhuravlev D. S. Esmedlyaeva T. L. Perova ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS
description	Emergence and development of pulmonary tuberculosis is often accompanied by the signs of immune system dysfunction. The key enzymes of purine metabolism, e.g., adenosine deaminase (ADA and its isoforms, i.e. ADA1, ADA1 protein complex, and ADA-2), ecto-5’-nucleotidase (5’-NC) controlling adenosine levels, may play an important role in regulation of cell-mediated immunity. We have correlated the parameters of purine metabolism with cytokine production in patients with fibro-cavernous pulmonary tuberculosis (FCT) with a severe specific process. Our studies have revealed an association between cytokine production and purine metabolism indexes, thus reflecting an important role of the latters in immunopathogenesis of the hyperchronic specific disorder. It is mainly referred to adenosine deaminase (ADA1 and ADA2) which are antagonistic in regulation of IL-17 and IL-18. A significantly decreased activity of intracellular ADA1, lowered CD26 concentrations, with lacking intercorrelation, along with increased activity of ecto-ADA-2 is, generally, typical to patients with fibrous-cavernous tuberculosis, thus being a possible marker for prediction of unfavorable hyperchronic specific process, being consistent with functional depletion of immunocompetent cells. Lack of the ADA/ectopeptidase complexes leads to an imbalance between adenosine supply and its deamination. Increased extracellular adenosine concentrations in the patients with severe specific processes may cause metabolic alterations of immunocompetent cells, thus complicating clinical course of the disease, e.g., contributing to enhancement and progression of pulmonary fibrosis.
format	article
author	M. Ye. Dyakova V. Yu. Zhuravlev D. S. Esmedlyaeva T. L. Perova
author_facet	M. Ye. Dyakova V. Yu. Zhuravlev D. S. Esmedlyaeva T. L. Perova
author_sort	M. Ye. Dyakova
title	ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS
title_short	ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS
title_full	ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS
title_fullStr	ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS
title_full_unstemmed	ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS
title_sort	role of purine metabolism enzymes in immune pathogenesis of fibro-cavernous pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/ede457f9020c4ef6987dc344cc8ca773
work_keys_str_mv	AT myedyakova roleofpurinemetabolismenzymesinimmunepathogenesisoffibrocavernouspulmonarytuberculosis AT vyuzhuravlev roleofpurinemetabolismenzymesinimmunepathogenesisoffibrocavernouspulmonarytuberculosis AT dsesmedlyaeva roleofpurinemetabolismenzymesinimmunepathogenesisoffibrocavernouspulmonarytuberculosis AT tlperova roleofpurinemetabolismenzymesinimmunepathogenesisoffibrocavernouspulmonarytuberculosis
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ROLE OF PURINE METABOLISM ENZYMES IN IMMUNE PATHOGENESIS OF FIBRO-CAVERNOUS PULMONARY TUBERCULOSIS

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