Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

DFNA5 is related to the caspase-dependent pyroptosis inducer gasdermin D. Here the authors find that DFNA5 is cleaved by caspase 3 and show this cleavage skews cells away from apoptosis into secondary necrosis, a form of cell death characterized by membrane ballooning similar to pyroptosis.

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Autores principales:	Corey Rogers, Teresa Fernandes-Alnemri, Lindsey Mayes, Diana Alnemri, Gino Cingolani, Emad S. Alnemri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ede72842f24b4015bf734b0a8c6dee76
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spelling	oai:doaj.org-article:ede72842f24b4015bf734b0a8c6dee762021-12-02T17:06:28ZCleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death10.1038/ncomms141282041-1723https://doaj.org/article/ede72842f24b4015bf734b0a8c6dee762017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14128https://doaj.org/toc/2041-1723DFNA5 is related to the caspase-dependent pyroptosis inducer gasdermin D. Here the authors find that DFNA5 is cleaved by caspase 3 and show this cleavage skews cells away from apoptosis into secondary necrosis, a form of cell death characterized by membrane ballooning similar to pyroptosis.Corey RogersTeresa Fernandes-AlnemriLindsey MayesDiana AlnemriGino CingolaniEmad S. AlnemriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Corey Rogers Teresa Fernandes-Alnemri Lindsey Mayes Diana Alnemri Gino Cingolani Emad S. Alnemri Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
description	DFNA5 is related to the caspase-dependent pyroptosis inducer gasdermin D. Here the authors find that DFNA5 is cleaved by caspase 3 and show this cleavage skews cells away from apoptosis into secondary necrosis, a form of cell death characterized by membrane ballooning similar to pyroptosis.
format	article
author	Corey Rogers Teresa Fernandes-Alnemri Lindsey Mayes Diana Alnemri Gino Cingolani Emad S. Alnemri
author_facet	Corey Rogers Teresa Fernandes-Alnemri Lindsey Mayes Diana Alnemri Gino Cingolani Emad S. Alnemri
author_sort	Corey Rogers
title	Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
title_short	Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
title_full	Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
title_fullStr	Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
title_full_unstemmed	Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
title_sort	cleavage of dfna5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ede72842f24b4015bf734b0a8c6dee76
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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

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