A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

A subset of CpG Island promoter genes are regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI), which become DNA hypermethylated and silenced in cancer. Here, the authors investigate the transcriptomic and epigenomic characteristics of PRC2-occupied CGI and free CGI across pan-cancer types.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yueyuan Zheng, Guowei Huang, Tiago C. Silva, Qian Yang, Yan-Yi Jiang, H. Phillip Koeffler, De-Chen Lin, Benjamin P. Berman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ede738b409a34065ac6b73e8d3099c51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ede738b409a34065ac6b73e8d3099c51
record_format	dspace
spelling	oai:doaj.org-article:ede738b409a34065ac6b73e8d3099c512021-12-02T17:17:17ZA pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes10.1038/s41467-021-22720-02041-1723https://doaj.org/article/ede738b409a34065ac6b73e8d3099c512021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22720-0https://doaj.org/toc/2041-1723A subset of CpG Island promoter genes are regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI), which become DNA hypermethylated and silenced in cancer. Here, the authors investigate the transcriptomic and epigenomic characteristics of PRC2-occupied CGI and free CGI across pan-cancer types.Yueyuan ZhengGuowei HuangTiago C. SilvaQian YangYan-Yi JiangH. Phillip KoefflerDe-Chen LinBenjamin P. BermanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yueyuan Zheng Guowei Huang Tiago C. Silva Qian Yang Yan-Yi Jiang H. Phillip Koeffler De-Chen Lin Benjamin P. Berman A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
description	A subset of CpG Island promoter genes are regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI), which become DNA hypermethylated and silenced in cancer. Here, the authors investigate the transcriptomic and epigenomic characteristics of PRC2-occupied CGI and free CGI across pan-cancer types.
format	article
author	Yueyuan Zheng Guowei Huang Tiago C. Silva Qian Yang Yan-Yi Jiang H. Phillip Koeffler De-Chen Lin Benjamin P. Berman
author_facet	Yueyuan Zheng Guowei Huang Tiago C. Silva Qian Yang Yan-Yi Jiang H. Phillip Koeffler De-Chen Lin Benjamin P. Berman
author_sort	Yueyuan Zheng
title	A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
title_short	A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
title_full	A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
title_fullStr	A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
title_full_unstemmed	A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
title_sort	pan-cancer analysis of cpg island gene regulation reveals extensive plasticity within polycomb target genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ede738b409a34065ac6b73e8d3099c51
work_keys_str_mv	AT yueyuanzheng apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT guoweihuang apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT tiagocsilva apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT qianyang apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT yanyijiang apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT hphillipkoeffler apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT dechenlin apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT benjaminpberman apancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT yueyuanzheng pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT guoweihuang pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT tiagocsilva pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT qianyang pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT yanyijiang pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT hphillipkoeffler pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT dechenlin pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes AT benjaminpberman pancanceranalysisofcpgislandgeneregulationrevealsextensiveplasticitywithinpolycombtargetgenes
_version_	1718381176231559168

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

Ejemplares similares