A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

A subset of CpG Island promoter genes are regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI), which become DNA hypermethylated and silenced in cancer. Here, the authors investigate the transcriptomic and epigenomic characteristics of PRC2-occupied CGI and free CGI across pan-cancer types.

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Autores principales: Yueyuan Zheng, Guowei Huang, Tiago C. Silva, Qian Yang, Yan-Yi Jiang, H. Phillip Koeffler, De-Chen Lin, Benjamin P. Berman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/ede738b409a34065ac6b73e8d3099c51
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