A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.

<h4>Background</h4>Cardiac events (CEs) are among the most serious late effects following childhood cancer treatment. To establish accurate risk estimates for the occurrence of CEs it is essential that they are graded in a valid and consistent manner, especially for international studies...

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Autores principales:	Elizabeth Lieke A M Feijen, Helena J van der Pal, Elvira C van Dalen, Renee L Mulder, Edit Bardi, Claudia Kuehni, Wim J E Tissing, Leontine C M Kremer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ede7eeee1dca4ec0baf0d6178f482af1
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spelling	oai:doaj.org-article:ede7eeee1dca4ec0baf0d6178f482af12021-11-25T06:09:13ZA new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.1932-620310.1371/journal.pone.0100432https://doaj.org/article/ede7eeee1dca4ec0baf0d6178f482af12014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25006805/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cardiac events (CEs) are among the most serious late effects following childhood cancer treatment. To establish accurate risk estimates for the occurrence of CEs it is essential that they are graded in a valid and consistent manner, especially for international studies. We therefore developed a data-extraction form and a set of flowcharts to grade CEs and tested the validity and consistency of this approach in a series of patients.<h4>Methods</h4>The Common Terminology Criteria for Adverse Events version 3.0 and 4.0 were used to define the CEs. Forty patients were randomly selected from a cohort of 72 subjects with known CEs that had been graded by a physician for an earlier study. To establish whether the new method was valid for appropriate grading, a non-physician graded the CEs by using the new method. To evaluate consistency of the grading, the same charts were graded again by two other non-physicians, one with receiving brief introduction and one with receiving extensive training on the new method. We calculated weighted Kappa statistics to quantify inter-observer agreement.<h4>Results</h4>The inter-observer agreement was 0.92 (95% CI 0.80-1.00) for validity, and 0.88 (0.79-0.98) and 0.99 (0.96-1.00) for consistency with the outcome assessors who had the brief introduction and the extensive training, respectively.<h4>Conclusions</h4>The newly developed standardized method to grade CEs using data from medical records has shown excellent validity and consistency. The study showed that the method can be correctly applied by researchers without a medical background, provided that they receive adequate training.Elizabeth Lieke A M FeijenHelena J van der PalElvira C van DalenRenee L MulderEdit BardiClaudia KuehniWim J E TissingLeontine C M KremerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e100432 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elizabeth Lieke A M Feijen Helena J van der Pal Elvira C van Dalen Renee L Mulder Edit Bardi Claudia Kuehni Wim J E Tissing Leontine C M Kremer A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.
description	<h4>Background</h4>Cardiac events (CEs) are among the most serious late effects following childhood cancer treatment. To establish accurate risk estimates for the occurrence of CEs it is essential that they are graded in a valid and consistent manner, especially for international studies. We therefore developed a data-extraction form and a set of flowcharts to grade CEs and tested the validity and consistency of this approach in a series of patients.<h4>Methods</h4>The Common Terminology Criteria for Adverse Events version 3.0 and 4.0 were used to define the CEs. Forty patients were randomly selected from a cohort of 72 subjects with known CEs that had been graded by a physician for an earlier study. To establish whether the new method was valid for appropriate grading, a non-physician graded the CEs by using the new method. To evaluate consistency of the grading, the same charts were graded again by two other non-physicians, one with receiving brief introduction and one with receiving extensive training on the new method. We calculated weighted Kappa statistics to quantify inter-observer agreement.<h4>Results</h4>The inter-observer agreement was 0.92 (95% CI 0.80-1.00) for validity, and 0.88 (0.79-0.98) and 0.99 (0.96-1.00) for consistency with the outcome assessors who had the brief introduction and the extensive training, respectively.<h4>Conclusions</h4>The newly developed standardized method to grade CEs using data from medical records has shown excellent validity and consistency. The study showed that the method can be correctly applied by researchers without a medical background, provided that they receive adequate training.
format	article
author	Elizabeth Lieke A M Feijen Helena J van der Pal Elvira C van Dalen Renee L Mulder Edit Bardi Claudia Kuehni Wim J E Tissing Leontine C M Kremer
author_facet	Elizabeth Lieke A M Feijen Helena J van der Pal Elvira C van Dalen Renee L Mulder Edit Bardi Claudia Kuehni Wim J E Tissing Leontine C M Kremer
author_sort	Elizabeth Lieke A M Feijen
title	A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.
title_short	A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.
title_full	A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.
title_fullStr	A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.
title_full_unstemmed	A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.
title_sort	new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ede7eeee1dca4ec0baf0d6178f482af1
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A new method to facilitate valid and consistent grading cardiac events in childhood cancer survivors using medical records.

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