phase1RMD: An R package for repeated measures dose-finding designs with novel toxicity and efficacy endpoints.

Traditional dose-finding designs are substantially inefficient for targeted agents and cancer immunotherapies by failing to incorporate efficacy signals, mild and moderate adverse events, and late, cumulative toxicities. However, the lack of user-friendly software is a barrier to the practical use o...

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Autores principales: Jun Yin, Yu Du, Rui Qin, Shihao Shen, Sumithra Mandrekar
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/ede96bfb61504b40971bf634b5050716
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