Post-Hypoxic Cells Promote Metastatic Recurrence after Chemotherapy Treatment in TNBC

Hypoxia occurs in 90% of solid tumors and is associated with treatment failure, relapse, and mortality. HIF-1α signaling promotes resistance to chemotherapy in cancer cell lines and murine models via multiple mechanisms including the enrichment of breast cancer stem cells (BCSCs). In this work, we u...

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Autores principales: Inês Godet, Mahelet Mamo, Andrea Thurnheer, D. Marc Rosen, Daniele M. Gilkes
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/edee0cfbbc51437ca7bef0f721d1a1a4
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