An Assessment of Ovarian Cancer Histotypes Across the African Diaspora

ObjectiveOvarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We so...

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Autores principales:	Sophia H. L. George, Ayodele Omotoso, Andre Pinto, Aisha Mustapha, Alex P. Sanchez-Covarrubias, Usman Aliyu Umar, Ali Bala Umar, Timothy Abiola Oluwasola, Clement Abu Okolo, Umeh Uchenna Anthony, Francis Ikechukwu Ukekwe, Maisaratu A. Bakari, Aminu M. C. Dahiru, Habiba Ibrahim Abdullahi, Bawa Ahmed Abimiku, Aisha Abdurrahman, Asmau Usman, Saad Aliyu Ahmed, Hadiza Abdullahi Usman, Abba Kabir, George Uchenna Eleje, Michael Emeka Chiemeka, Emily Nzeribe, Ikechukwu Nweke, SaiduAbubakar Kadas, Dauda E. Suleiman, Etim Ekanem, Umemmuo Maureen Uche, Jibrin Paul, Uzoma Maryrose Agwu, Felix O. Edegbe, Rose I. Anorlu, Adekunbiola Banjo, Kayode Olusegun Ajenifuja, Adegboyega Adisa Fawole, Ibrahim O. O. Kazeem, Francis Magaji, Olugbenga Silas, Boma Precious Athanasius, Nyengidiki Kennedy Tamunomie, Emem Bassey, Kunle Abudu, Ibrahim G. Ango, Kabiru Abdullahi, Ishak Lawal, Suleiman Aliyu Kabir, Victor Ekanem, Michael Ezeanochie, Usman Rahman Yahaya, Melissa Nicole Castillo, Vishal Bahall, Vikash Chatrani, Ian Brambury, Saida Bowe, Darron Halliday, George Bruney, Raleigh Butler, Camille Ragin, Folakemi Odedina, Srikar Chamala, Matthew Schlumbrecht, Bala Audu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ovarian cancer black women germ cell Caribbean Nigeria sex cord stromal Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/edeeadf80a724671b6c4bae55e4d51d7
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id	oai:doaj.org-article:edeeadf80a724671b6c4bae55e4d51d7
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institution	DOAJ
collection	DOAJ
language	EN
topic	ovarian cancer black women germ cell Caribbean Nigeria sex cord stromal Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ovarian cancer black women germ cell Caribbean Nigeria sex cord stromal Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sophia H. L. George Sophia H. L. George Sophia H. L. George Ayodele Omotoso Ayodele Omotoso Andre Pinto Andre Pinto Aisha Mustapha Aisha Mustapha Alex P. Sanchez-Covarrubias Usman Aliyu Umar Usman Aliyu Umar Ali Bala Umar Ali Bala Umar Timothy Abiola Oluwasola Timothy Abiola Oluwasola Clement Abu Okolo Clement Abu Okolo Umeh Uchenna Anthony Umeh Uchenna Anthony Francis Ikechukwu Ukekwe Francis Ikechukwu Ukekwe Maisaratu A. Bakari Maisaratu A. Bakari Aminu M. C. Dahiru Aminu M. C. Dahiru Habiba Ibrahim Abdullahi Habiba Ibrahim Abdullahi Bawa Ahmed Abimiku Bawa Ahmed Abimiku Aisha Abdurrahman Aisha Abdurrahman Asmau Usman Asmau Usman Saad Aliyu Ahmed Saad Aliyu Ahmed Hadiza Abdullahi Usman Hadiza Abdullahi Usman Abba Kabir Abba Kabir George Uchenna Eleje George Uchenna Eleje Michael Emeka Chiemeka Michael Emeka Chiemeka Emily Nzeribe Emily Nzeribe Ikechukwu Nweke Ikechukwu Nweke SaiduAbubakar Kadas SaiduAbubakar Kadas Dauda E. Suleiman Dauda E. Suleiman Etim Ekanem Etim Ekanem Umemmuo Maureen Uche Umemmuo Maureen Uche Jibrin Paul Jibrin Paul Uzoma Maryrose Agwu Uzoma Maryrose Agwu Felix O. Edegbe Felix O. Edegbe Rose I. Anorlu Rose I. Anorlu Adekunbiola Banjo Adekunbiola Banjo Kayode Olusegun Ajenifuja Kayode Olusegun Ajenifuja Adegboyega Adisa Fawole Adegboyega Adisa Fawole Ibrahim O. O. Kazeem Ibrahim O. O. Kazeem Francis Magaji Francis Magaji Olugbenga Silas Olugbenga Silas Boma Precious Athanasius Boma Precious Athanasius Nyengidiki Kennedy Tamunomie Nyengidiki Kennedy Tamunomie Emem Bassey Emem Bassey Kunle Abudu Kunle Abudu Ibrahim G. Ango Ibrahim G. Ango Kabiru Abdullahi Kabiru Abdullahi Ishak Lawal Ishak Lawal Suleiman Aliyu Kabir Suleiman Aliyu Kabir Victor Ekanem Victor Ekanem Michael Ezeanochie Michael Ezeanochie Usman Rahman Yahaya Usman Rahman Yahaya Melissa Nicole Castillo Vishal Bahall Vikash Chatrani Ian Brambury Ian Brambury Saida Bowe Saida Bowe Darron Halliday Darron Halliday George Bruney Raleigh Butler Raleigh Butler Camille Ragin Camille Ragin Folakemi Odedina Folakemi Odedina Srikar Chamala Matthew Schlumbrecht Matthew Schlumbrecht Matthew Schlumbrecht Bala Audu Bala Audu Bala Audu An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
description	ObjectiveOvarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora.MethodsPatients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05.ResultsNigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01).ConclusionThere is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.
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author	Sophia H. L. George Sophia H. L. George Sophia H. L. George Ayodele Omotoso Ayodele Omotoso Andre Pinto Andre Pinto Aisha Mustapha Aisha Mustapha Alex P. Sanchez-Covarrubias Usman Aliyu Umar Usman Aliyu Umar Ali Bala Umar Ali Bala Umar Timothy Abiola Oluwasola Timothy Abiola Oluwasola Clement Abu Okolo Clement Abu Okolo Umeh Uchenna Anthony Umeh Uchenna Anthony Francis Ikechukwu Ukekwe Francis Ikechukwu Ukekwe Maisaratu A. Bakari Maisaratu A. Bakari Aminu M. C. Dahiru Aminu M. C. Dahiru Habiba Ibrahim Abdullahi Habiba Ibrahim Abdullahi Bawa Ahmed Abimiku Bawa Ahmed Abimiku Aisha Abdurrahman Aisha Abdurrahman Asmau Usman Asmau Usman Saad Aliyu Ahmed Saad Aliyu Ahmed Hadiza Abdullahi Usman Hadiza Abdullahi Usman Abba Kabir Abba Kabir George Uchenna Eleje George Uchenna Eleje Michael Emeka Chiemeka Michael Emeka Chiemeka Emily Nzeribe Emily Nzeribe Ikechukwu Nweke Ikechukwu Nweke SaiduAbubakar Kadas SaiduAbubakar Kadas Dauda E. Suleiman Dauda E. Suleiman Etim Ekanem Etim Ekanem Umemmuo Maureen Uche Umemmuo Maureen Uche Jibrin Paul Jibrin Paul Uzoma Maryrose Agwu Uzoma Maryrose Agwu Felix O. Edegbe Felix O. Edegbe Rose I. Anorlu Rose I. Anorlu Adekunbiola Banjo Adekunbiola Banjo Kayode Olusegun Ajenifuja Kayode Olusegun Ajenifuja Adegboyega Adisa Fawole Adegboyega Adisa Fawole Ibrahim O. O. Kazeem Ibrahim O. O. Kazeem Francis Magaji Francis Magaji Olugbenga Silas Olugbenga Silas Boma Precious Athanasius Boma Precious Athanasius Nyengidiki Kennedy Tamunomie Nyengidiki Kennedy Tamunomie Emem Bassey Emem Bassey Kunle Abudu Kunle Abudu Ibrahim G. Ango Ibrahim G. Ango Kabiru Abdullahi Kabiru Abdullahi Ishak Lawal Ishak Lawal Suleiman Aliyu Kabir Suleiman Aliyu Kabir Victor Ekanem Victor Ekanem Michael Ezeanochie Michael Ezeanochie Usman Rahman Yahaya Usman Rahman Yahaya Melissa Nicole Castillo Vishal Bahall Vikash Chatrani Ian Brambury Ian Brambury Saida Bowe Saida Bowe Darron Halliday Darron Halliday George Bruney Raleigh Butler Raleigh Butler Camille Ragin Camille Ragin Folakemi Odedina Folakemi Odedina Srikar Chamala Matthew Schlumbrecht Matthew Schlumbrecht Matthew Schlumbrecht Bala Audu Bala Audu Bala Audu
author_facet	Sophia H. L. George Sophia H. L. George Sophia H. L. George Ayodele Omotoso Ayodele Omotoso Andre Pinto Andre Pinto Aisha Mustapha Aisha Mustapha Alex P. Sanchez-Covarrubias Usman Aliyu Umar Usman Aliyu Umar Ali Bala Umar Ali Bala Umar Timothy Abiola Oluwasola Timothy Abiola Oluwasola Clement Abu Okolo Clement Abu Okolo Umeh Uchenna Anthony Umeh Uchenna Anthony Francis Ikechukwu Ukekwe Francis Ikechukwu Ukekwe Maisaratu A. Bakari Maisaratu A. Bakari Aminu M. C. Dahiru Aminu M. C. Dahiru Habiba Ibrahim Abdullahi Habiba Ibrahim Abdullahi Bawa Ahmed Abimiku Bawa Ahmed Abimiku Aisha Abdurrahman Aisha Abdurrahman Asmau Usman Asmau Usman Saad Aliyu Ahmed Saad Aliyu Ahmed Hadiza Abdullahi Usman Hadiza Abdullahi Usman Abba Kabir Abba Kabir George Uchenna Eleje George Uchenna Eleje Michael Emeka Chiemeka Michael Emeka Chiemeka Emily Nzeribe Emily Nzeribe Ikechukwu Nweke Ikechukwu Nweke SaiduAbubakar Kadas SaiduAbubakar Kadas Dauda E. Suleiman Dauda E. Suleiman Etim Ekanem Etim Ekanem Umemmuo Maureen Uche Umemmuo Maureen Uche Jibrin Paul Jibrin Paul Uzoma Maryrose Agwu Uzoma Maryrose Agwu Felix O. Edegbe Felix O. Edegbe Rose I. Anorlu Rose I. Anorlu Adekunbiola Banjo Adekunbiola Banjo Kayode Olusegun Ajenifuja Kayode Olusegun Ajenifuja Adegboyega Adisa Fawole Adegboyega Adisa Fawole Ibrahim O. O. Kazeem Ibrahim O. O. Kazeem Francis Magaji Francis Magaji Olugbenga Silas Olugbenga Silas Boma Precious Athanasius Boma Precious Athanasius Nyengidiki Kennedy Tamunomie Nyengidiki Kennedy Tamunomie Emem Bassey Emem Bassey Kunle Abudu Kunle Abudu Ibrahim G. Ango Ibrahim G. Ango Kabiru Abdullahi Kabiru Abdullahi Ishak Lawal Ishak Lawal Suleiman Aliyu Kabir Suleiman Aliyu Kabir Victor Ekanem Victor Ekanem Michael Ezeanochie Michael Ezeanochie Usman Rahman Yahaya Usman Rahman Yahaya Melissa Nicole Castillo Vishal Bahall Vikash Chatrani Ian Brambury Ian Brambury Saida Bowe Saida Bowe Darron Halliday Darron Halliday George Bruney Raleigh Butler Raleigh Butler Camille Ragin Camille Ragin Folakemi Odedina Folakemi Odedina Srikar Chamala Matthew Schlumbrecht Matthew Schlumbrecht Matthew Schlumbrecht Bala Audu Bala Audu Bala Audu
author_sort	Sophia H. L. George
title	An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
title_short	An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
title_full	An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
title_fullStr	An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
title_full_unstemmed	An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
title_sort	assessment of ovarian cancer histotypes across the african diaspora
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/edeeadf80a724671b6c4bae55e4d51d7
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spelling	oai:doaj.org-article:edeeadf80a724671b6c4bae55e4d51d72021-12-01T07:42:22ZAn Assessment of Ovarian Cancer Histotypes Across the African Diaspora2234-943X10.3389/fonc.2021.732443https://doaj.org/article/edeeadf80a724671b6c4bae55e4d51d72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.732443/fullhttps://doaj.org/toc/2234-943XObjectiveOvarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora.MethodsPatients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05.ResultsNigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01).ConclusionThere is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.Sophia H. L. GeorgeSophia H. L. GeorgeSophia H. L. GeorgeAyodele OmotosoAyodele OmotosoAndre PintoAndre PintoAisha MustaphaAisha MustaphaAlex P. Sanchez-CovarrubiasUsman Aliyu UmarUsman Aliyu UmarAli Bala UmarAli Bala UmarTimothy Abiola OluwasolaTimothy Abiola OluwasolaClement Abu OkoloClement Abu OkoloUmeh Uchenna AnthonyUmeh Uchenna AnthonyFrancis Ikechukwu UkekweFrancis Ikechukwu UkekweMaisaratu A. BakariMaisaratu A. BakariAminu M. C. DahiruAminu M. C. DahiruHabiba Ibrahim AbdullahiHabiba Ibrahim AbdullahiBawa Ahmed AbimikuBawa Ahmed AbimikuAisha AbdurrahmanAisha AbdurrahmanAsmau UsmanAsmau UsmanSaad Aliyu AhmedSaad Aliyu AhmedHadiza Abdullahi UsmanHadiza Abdullahi UsmanAbba KabirAbba KabirGeorge Uchenna ElejeGeorge Uchenna ElejeMichael Emeka ChiemekaMichael Emeka ChiemekaEmily NzeribeEmily NzeribeIkechukwu NwekeIkechukwu NwekeSaiduAbubakar KadasSaiduAbubakar KadasDauda E. SuleimanDauda E. SuleimanEtim EkanemEtim EkanemUmemmuo Maureen UcheUmemmuo Maureen UcheJibrin PaulJibrin PaulUzoma Maryrose AgwuUzoma Maryrose AgwuFelix O. EdegbeFelix O. EdegbeRose I. AnorluRose I. AnorluAdekunbiola BanjoAdekunbiola BanjoKayode Olusegun AjenifujaKayode Olusegun AjenifujaAdegboyega Adisa FawoleAdegboyega Adisa FawoleIbrahim O. O. KazeemIbrahim O. O. KazeemFrancis MagajiFrancis MagajiOlugbenga SilasOlugbenga SilasBoma Precious AthanasiusBoma Precious AthanasiusNyengidiki Kennedy TamunomieNyengidiki Kennedy TamunomieEmem BasseyEmem BasseyKunle AbuduKunle AbuduIbrahim G. AngoIbrahim G. AngoKabiru AbdullahiKabiru AbdullahiIshak LawalIshak LawalSuleiman Aliyu KabirSuleiman Aliyu KabirVictor EkanemVictor EkanemMichael EzeanochieMichael EzeanochieUsman Rahman YahayaUsman Rahman YahayaMelissa Nicole CastilloVishal BahallVikash ChatraniIan BramburyIan BramburySaida BoweSaida BoweDarron HallidayDarron HallidayGeorge BruneyRaleigh ButlerRaleigh ButlerCamille RaginCamille RaginFolakemi OdedinaFolakemi OdedinaSrikar ChamalaMatthew SchlumbrechtMatthew SchlumbrechtMatthew SchlumbrechtBala AuduBala AuduBala AuduFrontiers Media S.A.articleovarian cancerblack womengerm cellCaribbeanNigeriasex cord stromalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)

An Assessment of Ovarian Cancer Histotypes Across the African Diaspora

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