IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY

Studying of immune interlayer value to tick-borne encephalitis virus in human population of the Transbaikalia Territory resulted from natural immunization of the healthy population in 31 Municipal areas in 2011–2016 is presented. Human selections were formed proportionally to the population size in...

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Autores principales:	A. O. Turanov, A. Y. Nikitin, E. I. Andaev
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Materias:	tick-borne virus encephalitis immune interlayer immune-enzyme analysis natural focus Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/edf06a8be6c54e379cad7a2eb8894181
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spelling	oai:doaj.org-article:edf06a8be6c54e379cad7a2eb88941812021-11-22T07:09:49ZIMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY2220-76192313-739810.15789/2220-7619-2018-3-335-340https://doaj.org/article/edf06a8be6c54e379cad7a2eb88941812018-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/783https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Studying of immune interlayer value to tick-borne encephalitis virus in human population of the Transbaikalia Territory resulted from natural immunization of the healthy population in 31 Municipal areas in 2011–2016 is presented. Human selections were formed proportionally to the population size in the concrete human settlement among persons of the various age and professional groups living at this territory not less than 10 years and unvaccinated against tick-borne encephalitis virus. Total 4367 blood sera were investigated. Laboratory testing for antibodies of G class to tick-borne encephalitis virus in blood sera of the human population was performed by immune-enzyme analysis using a set of reagents “VektoVKE-IgG” of Joint-Stock Company “Vektor-Best” (Novosibirsk city). The monitoring data indicated the presence of natural immunity to tick-borne encephalitis virus in the human population. Mean annual level of immune interlayer in Municipal areas varied from 3.1 to 52.7% (in Transbaikalian Territory — 13.1±0.51%). High level (from 20 to 52.7%) was characteristic for mountain-taiga-forest-steppe zone (Krasnochikoisky — 23.8±3.36%; Uletovsky — 52.4±4.48%; Gazimuro-Zavodsky — 29.4±4.94% districts) and mountain-tundra-taiga zone (Tungokochensky district — 20.0±3.58%). In steppe zone the level of immune interlayer was lower and observed in districts with elements of south-taiga larch and pine forests. It was established that levels of the immune interlayer in human population living in mountain-taiga-foreststeppe and mountain-tundra-taiga zones authentically higher than in steppe area — t = 3.8; Р < 0.001 and t = 2.27; Р < 0.05, respectively. Distinctions in the value of the immune interlayer between mountain-tundra-taiga and mountain-taigaforest-steppe zones were non-authentic: t = 0.1; P > 0.05. Active circulation of tick-borne encephalitis virus was accompanied by authentic (Р < 0.01) increase of the interlayer in persons with the virus antibodies in 2014–2016 (15.8±0.69%) in comparison with 2011–2013 (9.7±0.78%). Also it was noted in all landscape zones: in steppe zone the increase was to 42.8% (P > 0.05); in mountain-taiga-forest-steppe — to 61.3% (P > 0.05); in mountain-tundra-taiga — to 150.0% (Р < 0.01). It was not possible to reveal correlation between the recourse for medical aid and the value of immune interlayer in the population formed as a result of latent immunization. Results of the population immunity studying essentially expand our knowledge about the condition of the natural foci and dynamics of development of the epidemic processes in it, and can be used at planning of the preventive actions.A. O. TuranovA. Y. NikitinE. I. AndaevSankt-Peterburg : NIIÈM imeni Pasteraarticletick-borne virus encephalitisimmune interlayerimmune-enzyme analysisnatural focusInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 8, Iss 3, Pp 335-340 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	tick-borne virus encephalitis immune interlayer immune-enzyme analysis natural focus Infectious and parasitic diseases RC109-216
spellingShingle	tick-borne virus encephalitis immune interlayer immune-enzyme analysis natural focus Infectious and parasitic diseases RC109-216 A. O. Turanov A. Y. Nikitin E. I. Andaev IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY
description	Studying of immune interlayer value to tick-borne encephalitis virus in human population of the Transbaikalia Territory resulted from natural immunization of the healthy population in 31 Municipal areas in 2011–2016 is presented. Human selections were formed proportionally to the population size in the concrete human settlement among persons of the various age and professional groups living at this territory not less than 10 years and unvaccinated against tick-borne encephalitis virus. Total 4367 blood sera were investigated. Laboratory testing for antibodies of G class to tick-borne encephalitis virus in blood sera of the human population was performed by immune-enzyme analysis using a set of reagents “VektoVKE-IgG” of Joint-Stock Company “Vektor-Best” (Novosibirsk city). The monitoring data indicated the presence of natural immunity to tick-borne encephalitis virus in the human population. Mean annual level of immune interlayer in Municipal areas varied from 3.1 to 52.7% (in Transbaikalian Territory — 13.1±0.51%). High level (from 20 to 52.7%) was characteristic for mountain-taiga-forest-steppe zone (Krasnochikoisky — 23.8±3.36%; Uletovsky — 52.4±4.48%; Gazimuro-Zavodsky — 29.4±4.94% districts) and mountain-tundra-taiga zone (Tungokochensky district — 20.0±3.58%). In steppe zone the level of immune interlayer was lower and observed in districts with elements of south-taiga larch and pine forests. It was established that levels of the immune interlayer in human population living in mountain-taiga-foreststeppe and mountain-tundra-taiga zones authentically higher than in steppe area — t = 3.8; Р < 0.001 and t = 2.27; Р < 0.05, respectively. Distinctions in the value of the immune interlayer between mountain-tundra-taiga and mountain-taigaforest-steppe zones were non-authentic: t = 0.1; P > 0.05. Active circulation of tick-borne encephalitis virus was accompanied by authentic (Р < 0.01) increase of the interlayer in persons with the virus antibodies in 2014–2016 (15.8±0.69%) in comparison with 2011–2013 (9.7±0.78%). Also it was noted in all landscape zones: in steppe zone the increase was to 42.8% (P > 0.05); in mountain-taiga-forest-steppe — to 61.3% (P > 0.05); in mountain-tundra-taiga — to 150.0% (Р < 0.01). It was not possible to reveal correlation between the recourse for medical aid and the value of immune interlayer in the population formed as a result of latent immunization. Results of the population immunity studying essentially expand our knowledge about the condition of the natural foci and dynamics of development of the epidemic processes in it, and can be used at planning of the preventive actions.
format	article
author	A. O. Turanov A. Y. Nikitin E. I. Andaev
author_facet	A. O. Turanov A. Y. Nikitin E. I. Andaev
author_sort	A. O. Turanov
title	IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY
title_short	IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY
title_full	IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY
title_fullStr	IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY
title_full_unstemmed	IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY
title_sort	immune interlayer to tick-borne encephalitis virus in human population of transbaikalia as an indicator of natural foci activity
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/edf06a8be6c54e379cad7a2eb8894181
work_keys_str_mv	AT aoturanov immuneinterlayertotickborneencephalitisvirusinhumanpopulationoftransbaikaliaasanindicatorofnaturalfociactivity AT aynikitin immuneinterlayertotickborneencephalitisvirusinhumanpopulationoftransbaikaliaasanindicatorofnaturalfociactivity AT eiandaev immuneinterlayertotickborneencephalitisvirusinhumanpopulationoftransbaikaliaasanindicatorofnaturalfociactivity
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IMMUNE INTERLAYER TO TICK-BORNE ENCEPHALITIS VIRUS IN HUMAN POPULATION OF TRANSBAIKALIA AS AN INDICATOR OF NATURAL FOCI ACTIVITY

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