Proteome activity landscapes of tumor cell lines determine drug responses

Proteome activity landscapes of tumor cell lines determine drug responses

Proteome activity has a major role in cancer progression and response to drugs. Here, the authors use comprehensive proteomic and phosphoproteomic data, in conjunction with drug-sensitivity screens, to generate a community resource consisting of landscapes of pathway and kinase activity across diffe...

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Autores principales: Martin Frejno, Chen Meng, Benjamin Ruprecht, Thomas Oellerich, Sebastian Scheich, Karin Kleigrewe, Enken Drecoll, Patroklos Samaras, Alexander Hogrebe, Dominic Helm, Julia Mergner, Jana Zecha, Stephanie Heinzlmeir, Mathias Wilhelm, Julia Dorn, Hans-Michael Kvasnicka, Hubert Serve, Wilko Weichert, Bernhard Kuster
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/edf0d26d1b5949468d163e5ba1741225
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spelling oai:doaj.org-article:edf0d26d1b5949468d163e5ba17412252021-12-02T17:57:17ZProteome activity landscapes of tumor cell lines determine drug responses10.1038/s41467-020-17336-92041-1723https://doaj.org/article/edf0d26d1b5949468d163e5ba17412252020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17336-9https://doaj.org/toc/2041-1723Proteome activity has a major role in cancer progression and response to drugs. Here, the authors use comprehensive proteomic and phosphoproteomic data, in conjunction with drug-sensitivity screens, to generate a community resource consisting of landscapes of pathway and kinase activity across different cell linesMartin FrejnoChen MengBenjamin RuprechtThomas OellerichSebastian ScheichKarin KleigreweEnken DrecollPatroklos SamarasAlexander HogrebeDominic HelmJulia MergnerJana ZechaStephanie HeinzlmeirMathias WilhelmJulia DornHans-Michael KvasnickaHubert ServeWilko WeichertBernhard KusterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Martin Frejno
Chen Meng
Benjamin Ruprecht
Thomas Oellerich
Sebastian Scheich
Karin Kleigrewe
Enken Drecoll
Patroklos Samaras
Alexander Hogrebe
Dominic Helm
Julia Mergner
Jana Zecha
Stephanie Heinzlmeir
Mathias Wilhelm
Julia Dorn
Hans-Michael Kvasnicka
Hubert Serve
Wilko Weichert
Bernhard Kuster
Proteome activity landscapes of tumor cell lines determine drug responses
description Proteome activity has a major role in cancer progression and response to drugs. Here, the authors use comprehensive proteomic and phosphoproteomic data, in conjunction with drug-sensitivity screens, to generate a community resource consisting of landscapes of pathway and kinase activity across different cell lines
format article
author Martin Frejno
Chen Meng
Benjamin Ruprecht
Thomas Oellerich
Sebastian Scheich
Karin Kleigrewe
Enken Drecoll
Patroklos Samaras
Alexander Hogrebe
Dominic Helm
Julia Mergner
Jana Zecha
Stephanie Heinzlmeir
Mathias Wilhelm
Julia Dorn
Hans-Michael Kvasnicka
Hubert Serve
Wilko Weichert
Bernhard Kuster
author_facet Martin Frejno
Chen Meng
Benjamin Ruprecht
Thomas Oellerich
Sebastian Scheich
Karin Kleigrewe
Enken Drecoll
Patroklos Samaras
Alexander Hogrebe
Dominic Helm
Julia Mergner
Jana Zecha
Stephanie Heinzlmeir
Mathias Wilhelm
Julia Dorn
Hans-Michael Kvasnicka
Hubert Serve
Wilko Weichert
Bernhard Kuster
author_sort Martin Frejno
title Proteome activity landscapes of tumor cell lines determine drug responses
title_short Proteome activity landscapes of tumor cell lines determine drug responses
title_full Proteome activity landscapes of tumor cell lines determine drug responses
title_fullStr Proteome activity landscapes of tumor cell lines determine drug responses
title_full_unstemmed Proteome activity landscapes of tumor cell lines determine drug responses
title_sort proteome activity landscapes of tumor cell lines determine drug responses
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/edf0d26d1b5949468d163e5ba1741225
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