Proteome activity landscapes of tumor cell lines determine drug responses
Proteome activity has a major role in cancer progression and response to drugs. Here, the authors use comprehensive proteomic and phosphoproteomic data, in conjunction with drug-sensitivity screens, to generate a community resource consisting of landscapes of pathway and kinase activity across diffe...
Guardado en:
Autores principales: | Martin Frejno, Chen Meng, Benjamin Ruprecht, Thomas Oellerich, Sebastian Scheich, Karin Kleigrewe, Enken Drecoll, Patroklos Samaras, Alexander Hogrebe, Dominic Helm, Julia Mergner, Jana Zecha, Stephanie Heinzlmeir, Mathias Wilhelm, Julia Dorn, Hans-Michael Kvasnicka, Hubert Serve, Wilko Weichert, Bernhard Kuster |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/edf0d26d1b5949468d163e5ba1741225 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
por: Bernhard Hoermann, et al.
Publicado: (2020) -
Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas.
por: Julia Slotta-Huspenina, et al.
Publicado: (2012) -
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML
por: Thomas Oellerich, et al.
Publicado: (2019) -
Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS
por: Yangyang Bian, et al.
Publicado: (2020) -
Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics
por: Mathias Wilhelm, et al.
Publicado: (2021)