CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES

The problem of regeneration of bone structure and joint cartilage is one of the priority programs of scientific research. Regulation of bone formation at the damage is carried out by complex set of factors. A reflection of the regeneration processes is the dynamics of blood parameters, among which a...

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Autores principales: G. .. Qiao, S. A. Lepekhova, L. V. Zaritskaya, E. V. Batunova, O. N. Postovaya, N. V. Tishkov, I. S. Kurganskiy, O. A. Goldberg, Y. I. Pivovarov
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Publicado: Scientific Сentre for Family Health and Human Reproduction Problems 2017
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spelling oai:doaj.org-article:edf252bec0aa4a56887152d1024017fc2021-11-23T06:14:37ZCHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES2541-94202587-959610.12737/article_59a614fd21bcc1.81958543https://doaj.org/article/edf252bec0aa4a56887152d1024017fc2017-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/626https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The problem of regeneration of bone structure and joint cartilage is one of the priority programs of scientific research. Regulation of bone formation at the damage is carried out by complex set of factors. A reflection of the regeneration processes is the dynamics of blood parameters, among which are the indicators of inflammatory reaction of the organism, and condition of phagocytosis system. One way to control the severity of impaired reparative regeneration is the analysis of immunological tests of the first order. The aim of our study was to investigate nonspecific resistance of the organism for any breach of reparative regeneration of bone in the lower leg. The study was performed on rabbits "Chinchilla" which simulated the breach of the terms of reparative regeneration. We assessed leukocyte profile and indicators of phagocytosis in experimental animals. Status of the phagocytic activity of blood neutrophils was evaluated on the following parameters: phagocytic index, phagocytic number, nitroblue tetrazolium test, the concentration of circulating immune complexes. We found broken shin bone reparative regeneration of rabbit at fiftieth day of observations is accompanied by leukocytosis with increased segmented neutrophils and a decrease in lymphocytes, inhibition of phagocytosis, and violation of the elimination of circulating immune complexes.G. .. QiaoS. A. LepekhovaL. V. ZaritskayaE. V. BatunovaO. N. PostovayaN. V. TishkovI. S. KurganskiyO. A. GoldbergY. I. PivovarovScientific Сentre for Family Health and Human Reproduction Problemsarticleimpaired reparative regeneration of the bonesnonspecific resistanceinflammationScienceQRUActa Biomedica Scientifica, Vol 2, Iss 2, Pp 89-94 (2017)
institution DOAJ
collection DOAJ
language RU
topic impaired reparative regeneration of the bones
nonspecific resistance
inflammation
Science
Q
spellingShingle impaired reparative regeneration of the bones
nonspecific resistance
inflammation
Science
Q
G. .. Qiao
S. A. Lepekhova
L. V. Zaritskaya
E. V. Batunova
O. N. Postovaya
N. V. Tishkov
I. S. Kurganskiy
O. A. Goldberg
Y. I. Pivovarov
CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES
description The problem of regeneration of bone structure and joint cartilage is one of the priority programs of scientific research. Regulation of bone formation at the damage is carried out by complex set of factors. A reflection of the regeneration processes is the dynamics of blood parameters, among which are the indicators of inflammatory reaction of the organism, and condition of phagocytosis system. One way to control the severity of impaired reparative regeneration is the analysis of immunological tests of the first order. The aim of our study was to investigate nonspecific resistance of the organism for any breach of reparative regeneration of bone in the lower leg. The study was performed on rabbits "Chinchilla" which simulated the breach of the terms of reparative regeneration. We assessed leukocyte profile and indicators of phagocytosis in experimental animals. Status of the phagocytic activity of blood neutrophils was evaluated on the following parameters: phagocytic index, phagocytic number, nitroblue tetrazolium test, the concentration of circulating immune complexes. We found broken shin bone reparative regeneration of rabbit at fiftieth day of observations is accompanied by leukocytosis with increased segmented neutrophils and a decrease in lymphocytes, inhibition of phagocytosis, and violation of the elimination of circulating immune complexes.
format article
author G. .. Qiao
S. A. Lepekhova
L. V. Zaritskaya
E. V. Batunova
O. N. Postovaya
N. V. Tishkov
I. S. Kurganskiy
O. A. Goldberg
Y. I. Pivovarov
author_facet G. .. Qiao
S. A. Lepekhova
L. V. Zaritskaya
E. V. Batunova
O. N. Postovaya
N. V. Tishkov
I. S. Kurganskiy
O. A. Goldberg
Y. I. Pivovarov
author_sort G. .. Qiao
title CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES
title_short CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES
title_full CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES
title_fullStr CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES
title_full_unstemmed CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES
title_sort changes in the indices of nonspecific resistance of an organism in modeling disturbed reparative regeneration of shin bones
publisher Scientific Сentre for Family Health and Human Reproduction Problems
publishDate 2017
url https://doaj.org/article/edf252bec0aa4a56887152d1024017fc
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