CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES
The problem of regeneration of bone structure and joint cartilage is one of the priority programs of scientific research. Regulation of bone formation at the damage is carried out by complex set of factors. A reflection of the regeneration processes is the dynamics of blood parameters, among which a...
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Scientific Сentre for Family Health and Human Reproduction Problems
2017
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oai:doaj.org-article:edf252bec0aa4a56887152d1024017fc2021-11-23T06:14:37ZCHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES2541-94202587-959610.12737/article_59a614fd21bcc1.81958543https://doaj.org/article/edf252bec0aa4a56887152d1024017fc2017-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/626https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The problem of regeneration of bone structure and joint cartilage is one of the priority programs of scientific research. Regulation of bone formation at the damage is carried out by complex set of factors. A reflection of the regeneration processes is the dynamics of blood parameters, among which are the indicators of inflammatory reaction of the organism, and condition of phagocytosis system. One way to control the severity of impaired reparative regeneration is the analysis of immunological tests of the first order. The aim of our study was to investigate nonspecific resistance of the organism for any breach of reparative regeneration of bone in the lower leg. The study was performed on rabbits "Chinchilla" which simulated the breach of the terms of reparative regeneration. We assessed leukocyte profile and indicators of phagocytosis in experimental animals. Status of the phagocytic activity of blood neutrophils was evaluated on the following parameters: phagocytic index, phagocytic number, nitroblue tetrazolium test, the concentration of circulating immune complexes. We found broken shin bone reparative regeneration of rabbit at fiftieth day of observations is accompanied by leukocytosis with increased segmented neutrophils and a decrease in lymphocytes, inhibition of phagocytosis, and violation of the elimination of circulating immune complexes.G. .. QiaoS. A. LepekhovaL. V. ZaritskayaE. V. BatunovaO. N. PostovayaN. V. TishkovI. S. KurganskiyO. A. GoldbergY. I. PivovarovScientific Сentre for Family Health and Human Reproduction Problemsarticleimpaired reparative regeneration of the bonesnonspecific resistanceinflammationScienceQRUActa Biomedica Scientifica, Vol 2, Iss 2, Pp 89-94 (2017) |
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impaired reparative regeneration of the bones nonspecific resistance inflammation Science Q |
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impaired reparative regeneration of the bones nonspecific resistance inflammation Science Q G. .. Qiao S. A. Lepekhova L. V. Zaritskaya E. V. Batunova O. N. Postovaya N. V. Tishkov I. S. Kurganskiy O. A. Goldberg Y. I. Pivovarov CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES |
description |
The problem of regeneration of bone structure and joint cartilage is one of the priority programs of scientific research. Regulation of bone formation at the damage is carried out by complex set of factors. A reflection of the regeneration processes is the dynamics of blood parameters, among which are the indicators of inflammatory reaction of the organism, and condition of phagocytosis system. One way to control the severity of impaired reparative regeneration is the analysis of immunological tests of the first order. The aim of our study was to investigate nonspecific resistance of the organism for any breach of reparative regeneration of bone in the lower leg. The study was performed on rabbits "Chinchilla" which simulated the breach of the terms of reparative regeneration. We assessed leukocyte profile and indicators of phagocytosis in experimental animals. Status of the phagocytic activity of blood neutrophils was evaluated on the following parameters: phagocytic index, phagocytic number, nitroblue tetrazolium test, the concentration of circulating immune complexes. We found broken shin bone reparative regeneration of rabbit at fiftieth day of observations is accompanied by leukocytosis with increased segmented neutrophils and a decrease in lymphocytes, inhibition of phagocytosis, and violation of the elimination of circulating immune complexes. |
format |
article |
author |
G. .. Qiao S. A. Lepekhova L. V. Zaritskaya E. V. Batunova O. N. Postovaya N. V. Tishkov I. S. Kurganskiy O. A. Goldberg Y. I. Pivovarov |
author_facet |
G. .. Qiao S. A. Lepekhova L. V. Zaritskaya E. V. Batunova O. N. Postovaya N. V. Tishkov I. S. Kurganskiy O. A. Goldberg Y. I. Pivovarov |
author_sort |
G. .. Qiao |
title |
CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES |
title_short |
CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES |
title_full |
CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES |
title_fullStr |
CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES |
title_full_unstemmed |
CHANGES IN THE INDICES OF NONSPECIFIC RESISTANCE OF AN ORGANISM IN MODELING DISTURBED REPARATIVE REGENERATION OF SHIN BONES |
title_sort |
changes in the indices of nonspecific resistance of an organism in modeling disturbed reparative regeneration of shin bones |
publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
publishDate |
2017 |
url |
https://doaj.org/article/edf252bec0aa4a56887152d1024017fc |
work_keys_str_mv |
AT gqiao changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT salepekhova changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT lvzaritskaya changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT evbatunova changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT onpostovaya changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT nvtishkov changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT iskurganskiy changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT oagoldberg changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones AT yipivovarov changesintheindicesofnonspecificresistanceofanorganisminmodelingdisturbedreparativeregenerationofshinbones |
_version_ |
1718417042564972544 |