Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

The classification of breast lesions as indolent or aggressive to tailor treatment is crucial. Here, the authors use single-cell transcriptomics and multiparametric imaging of a breast cancer mouse model, report distinct tumor-immune features for the two types of lesions, and suggest the role of IL-...

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Autores principales:	Vidya C. Sinha, Amanda L. Rinkenbaugh, Mingchu Xu, Xinhui Zhou, Xiaomei Zhang, Sabrina Jeter-Jones, Jiansu Shao, Yuan Qi, John A. Zebala, Dean Y. Maeda, Florencia McAllister, Helen Piwnica-Worms
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/edf450673bba4946ad0410cdc2344397
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spelling	oai:doaj.org-article:edf450673bba4946ad0410cdc23443972021-12-02T18:01:16ZSingle-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast10.1038/s41467-021-25240-z2041-1723https://doaj.org/article/edf450673bba4946ad0410cdc23443972021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25240-zhttps://doaj.org/toc/2041-1723The classification of breast lesions as indolent or aggressive to tailor treatment is crucial. Here, the authors use single-cell transcriptomics and multiparametric imaging of a breast cancer mouse model, report distinct tumor-immune features for the two types of lesions, and suggest the role of IL-17 signaling in disease progression.Vidya C. SinhaAmanda L. RinkenbaughMingchu XuXinhui ZhouXiaomei ZhangSabrina Jeter-JonesJiansu ShaoYuan QiJohn A. ZebalaDean Y. MaedaFlorencia McAllisterHelen Piwnica-WormsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vidya C. Sinha Amanda L. Rinkenbaugh Mingchu Xu Xinhui Zhou Xiaomei Zhang Sabrina Jeter-Jones Jiansu Shao Yuan Qi John A. Zebala Dean Y. Maeda Florencia McAllister Helen Piwnica-Worms Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
description	The classification of breast lesions as indolent or aggressive to tailor treatment is crucial. Here, the authors use single-cell transcriptomics and multiparametric imaging of a breast cancer mouse model, report distinct tumor-immune features for the two types of lesions, and suggest the role of IL-17 signaling in disease progression.
format	article
author	Vidya C. Sinha Amanda L. Rinkenbaugh Mingchu Xu Xinhui Zhou Xiaomei Zhang Sabrina Jeter-Jones Jiansu Shao Yuan Qi John A. Zebala Dean Y. Maeda Florencia McAllister Helen Piwnica-Worms
author_facet	Vidya C. Sinha Amanda L. Rinkenbaugh Mingchu Xu Xinhui Zhou Xiaomei Zhang Sabrina Jeter-Jones Jiansu Shao Yuan Qi John A. Zebala Dean Y. Maeda Florencia McAllister Helen Piwnica-Worms
author_sort	Vidya C. Sinha
title	Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
title_short	Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
title_full	Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
title_fullStr	Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
title_full_unstemmed	Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
title_sort	single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edf450673bba4946ad0410cdc2344397
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Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

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