Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming post-injury scar through cell-autonomous depositi...

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Autores principales: Filipa C. Simões, Thomas J. Cahill, Amy Kenyon, Daria Gavriouchkina, Joaquim M. Vieira, Xin Sun, Daniela Pezzolla, Christophe Ravaud, Eva Masmanian, Michael Weinberger, Sarah Mayes, Madeleine E. Lemieux, Damien N. Barnette, Mala Gunadasa-Rohling, Ruth M. Williams, David R. Greaves, Le A. Trinh, Scott E. Fraser, Sarah L. Dallas, Robin P. Choudhury, Tatjana Sauka-Spengler, Paul R. Riley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/edf55153a7b34a528c084339f4ceeac3
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spelling oai:doaj.org-article:edf55153a7b34a528c084339f4ceeac32021-12-02T14:42:46ZMacrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair10.1038/s41467-019-14263-22041-1723https://doaj.org/article/edf55153a7b34a528c084339f4ceeac32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14263-2https://doaj.org/toc/2041-1723Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.Filipa C. SimõesThomas J. CahillAmy KenyonDaria GavriouchkinaJoaquim M. VieiraXin SunDaniela PezzollaChristophe RavaudEva MasmanianMichael WeinbergerSarah MayesMadeleine E. LemieuxDamien N. BarnetteMala Gunadasa-RohlingRuth M. WilliamsDavid R. GreavesLe A. TrinhScott E. FraserSarah L. DallasRobin P. ChoudhuryTatjana Sauka-SpenglerPaul R. RileyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Filipa C. Simões
Thomas J. Cahill
Amy Kenyon
Daria Gavriouchkina
Joaquim M. Vieira
Xin Sun
Daniela Pezzolla
Christophe Ravaud
Eva Masmanian
Michael Weinberger
Sarah Mayes
Madeleine E. Lemieux
Damien N. Barnette
Mala Gunadasa-Rohling
Ruth M. Williams
David R. Greaves
Le A. Trinh
Scott E. Fraser
Sarah L. Dallas
Robin P. Choudhury
Tatjana Sauka-Spengler
Paul R. Riley
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
description Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.
format article
author Filipa C. Simões
Thomas J. Cahill
Amy Kenyon
Daria Gavriouchkina
Joaquim M. Vieira
Xin Sun
Daniela Pezzolla
Christophe Ravaud
Eva Masmanian
Michael Weinberger
Sarah Mayes
Madeleine E. Lemieux
Damien N. Barnette
Mala Gunadasa-Rohling
Ruth M. Williams
David R. Greaves
Le A. Trinh
Scott E. Fraser
Sarah L. Dallas
Robin P. Choudhury
Tatjana Sauka-Spengler
Paul R. Riley
author_facet Filipa C. Simões
Thomas J. Cahill
Amy Kenyon
Daria Gavriouchkina
Joaquim M. Vieira
Xin Sun
Daniela Pezzolla
Christophe Ravaud
Eva Masmanian
Michael Weinberger
Sarah Mayes
Madeleine E. Lemieux
Damien N. Barnette
Mala Gunadasa-Rohling
Ruth M. Williams
David R. Greaves
Le A. Trinh
Scott E. Fraser
Sarah L. Dallas
Robin P. Choudhury
Tatjana Sauka-Spengler
Paul R. Riley
author_sort Filipa C. Simões
title Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
title_short Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
title_full Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
title_fullStr Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
title_full_unstemmed Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
title_sort macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/edf55153a7b34a528c084339f4ceeac3
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