The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments

Abstract The composition and function of intestinal microbial communities are important for human health. However, these intestinal floras are sensitive to changes in the environment. Adverse changes to intestinal flora can affect the health of astronauts, resulting in difficulties in implementing s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peiming Sun, Jiaqi Yang, Bo Wang, Huan Ma, Yin Zhang, Jinhu Guo, Xiaoping Chen, Jianwei Zhao, Hongwei Sun, Jianwu Yang, Heming Yang, Yan Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edfdc232a5bb4b6f8743df64aa7dc885
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:edfdc232a5bb4b6f8743df64aa7dc885
record_format	dspace
spelling	oai:doaj.org-article:edfdc232a5bb4b6f8743df64aa7dc8852021-12-02T15:56:49ZThe effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments10.1038/s41598-021-91077-72045-2322https://doaj.org/article/edfdc232a5bb4b6f8743df64aa7dc8852021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91077-7https://doaj.org/toc/2045-2322Abstract The composition and function of intestinal microbial communities are important for human health. However, these intestinal floras are sensitive to changes in the environment. Adverse changes to intestinal flora can affect the health of astronauts, resulting in difficulties in implementing space missions. We randomly divided mice into three groups and placed each group in either a normal environment, simulated microgravity environment or a combined effects environment, which included simulated microgravity, low pressure and noise. Fecal samples of the mice were collected for follow-up analysis based on metagenomics technology. With the influence of different space environmental factors, the species composition at the phylum and genus levels were significantly affected by the combined effects environment, especially the abundance of the Firmicutes and Bacteroidetes. Furthermore, screening was conducted to identify biomarkers that could be regarded as environmental markers. And there have also been some noticeable changes in the function of intestinal floras. Moreover, the abundance of antibiotic resistance genes (ARGs) was also found to be changed under different environmental conditions, such as bacitracin and vancomycin. The combined effects environment could significantly affect the species composition, function, and the expression of ARGs of intestinal flora of mice which may provide a theoretical basis for space medical supervision and healthcare.Peiming SunJiaqi YangBo WangHuan MaYin ZhangJinhu GuoXiaoping ChenJianwei ZhaoHongwei SunJianwu YangHeming YangYan CuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peiming Sun Jiaqi Yang Bo Wang Huan Ma Yin Zhang Jinhu Guo Xiaoping Chen Jianwei Zhao Hongwei Sun Jianwu Yang Heming Yang Yan Cui The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments
description	Abstract The composition and function of intestinal microbial communities are important for human health. However, these intestinal floras are sensitive to changes in the environment. Adverse changes to intestinal flora can affect the health of astronauts, resulting in difficulties in implementing space missions. We randomly divided mice into three groups and placed each group in either a normal environment, simulated microgravity environment or a combined effects environment, which included simulated microgravity, low pressure and noise. Fecal samples of the mice were collected for follow-up analysis based on metagenomics technology. With the influence of different space environmental factors, the species composition at the phylum and genus levels were significantly affected by the combined effects environment, especially the abundance of the Firmicutes and Bacteroidetes. Furthermore, screening was conducted to identify biomarkers that could be regarded as environmental markers. And there have also been some noticeable changes in the function of intestinal floras. Moreover, the abundance of antibiotic resistance genes (ARGs) was also found to be changed under different environmental conditions, such as bacitracin and vancomycin. The combined effects environment could significantly affect the species composition, function, and the expression of ARGs of intestinal flora of mice which may provide a theoretical basis for space medical supervision and healthcare.
format	article
author	Peiming Sun Jiaqi Yang Bo Wang Huan Ma Yin Zhang Jinhu Guo Xiaoping Chen Jianwei Zhao Hongwei Sun Jianwu Yang Heming Yang Yan Cui
author_facet	Peiming Sun Jiaqi Yang Bo Wang Huan Ma Yin Zhang Jinhu Guo Xiaoping Chen Jianwei Zhao Hongwei Sun Jianwu Yang Heming Yang Yan Cui
author_sort	Peiming Sun
title	The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments
title_short	The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments
title_full	The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments
title_fullStr	The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments
title_full_unstemmed	The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments
title_sort	effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edfdc232a5bb4b6f8743df64aa7dc885
work_keys_str_mv	AT peimingsun theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jiaqiyang theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT bowang theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT huanma theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT yinzhang theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jinhuguo theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT xiaopingchen theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jianweizhao theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT hongweisun theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jianwuyang theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT hemingyang theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT yancui theeffectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT peimingsun effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jiaqiyang effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT bowang effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT huanma effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT yinzhang effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jinhuguo effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT xiaopingchen effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jianweizhao effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT hongweisun effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT jianwuyang effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT hemingyang effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments AT yancui effectsofcombinedenvironmentalfactorsontheintestinalfloraofmicebasedongroundsimulationexperiments
_version_	1718385425930780672

The effects of combined environmental factors on the intestinal flora of mice based on ground simulation experiments

Ejemplares similares