Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Interleukin-2 (IL-2) signaling is required for regulatory T (Treg) cell differentiation in the thymus, but its function in peripheral Tregs is still unclear. Here the authors show, using inducible deletion of IL-2 receptor subunit CD25, that IL-2 signaling is essential for maintaining peripheral Tre...

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Autores principales:	Kevin H. Toomer, Jen Bon Lui, Norman H. Altman, Yuguang Ban, Xi Chen, Thomas R. Malek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/edffae69c74843b0943c3bedba105ea2
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spelling	oai:doaj.org-article:edffae69c74843b0943c3bedba105ea22021-12-02T16:57:23ZEssential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells10.1038/s41467-019-08960-12041-1723https://doaj.org/article/edffae69c74843b0943c3bedba105ea22019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08960-1https://doaj.org/toc/2041-1723Interleukin-2 (IL-2) signaling is required for regulatory T (Treg) cell differentiation in the thymus, but its function in peripheral Tregs is still unclear. Here the authors show, using inducible deletion of IL-2 receptor subunit CD25, that IL-2 signaling is essential for maintaining peripheral Treg homeostasis, but dispensable for lineage stability.Kevin H. ToomerJen Bon LuiNorman H. AltmanYuguang BanXi ChenThomas R. MalekNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin H. Toomer Jen Bon Lui Norman H. Altman Yuguang Ban Xi Chen Thomas R. Malek Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
description	Interleukin-2 (IL-2) signaling is required for regulatory T (Treg) cell differentiation in the thymus, but its function in peripheral Tregs is still unclear. Here the authors show, using inducible deletion of IL-2 receptor subunit CD25, that IL-2 signaling is essential for maintaining peripheral Treg homeostasis, but dispensable for lineage stability.
format	article
author	Kevin H. Toomer Jen Bon Lui Norman H. Altman Yuguang Ban Xi Chen Thomas R. Malek
author_facet	Kevin H. Toomer Jen Bon Lui Norman H. Altman Yuguang Ban Xi Chen Thomas R. Malek
author_sort	Kevin H. Toomer
title	Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
title_short	Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
title_full	Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
title_fullStr	Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
title_full_unstemmed	Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
title_sort	essential and non-overlapping il-2rα-dependent processes for thymic development and peripheral homeostasis of regulatory t cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/edffae69c74843b0943c3bedba105ea2
work_keys_str_mv	AT kevinhtoomer essentialandnonoverlappingil2radependentprocessesforthymicdevelopmentandperipheralhomeostasisofregulatorytcells AT jenbonlui essentialandnonoverlappingil2radependentprocessesforthymicdevelopmentandperipheralhomeostasisofregulatorytcells AT normanhaltman essentialandnonoverlappingil2radependentprocessesforthymicdevelopmentandperipheralhomeostasisofregulatorytcells AT yuguangban essentialandnonoverlappingil2radependentprocessesforthymicdevelopmentandperipheralhomeostasisofregulatorytcells AT xichen essentialandnonoverlappingil2radependentprocessesforthymicdevelopmentandperipheralhomeostasisofregulatorytcells AT thomasrmalek essentialandnonoverlappingil2radependentprocessesforthymicdevelopmentandperipheralhomeostasisofregulatorytcells
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Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

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