Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics
Abstract We performed an observational study with very-low-birth weight infants (VLBWI) ≤33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n = 8534, n = 6229 received probiotics). The primary objectives of our study were (a) to assess the effect of Lactobacillus acido...
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Nature Portfolio
2017
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oai:doaj.org-article:edfff3111e9848699499ca171dfd09c82021-12-02T12:31:50ZLactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics10.1038/s41598-017-06161-82045-2322https://doaj.org/article/edfff3111e9848699499ca171dfd09c82017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06161-8https://doaj.org/toc/2045-2322Abstract We performed an observational study with very-low-birth weight infants (VLBWI) ≤33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n = 8534, n = 6229 received probiotics). The primary objectives of our study were (a) to assess the effect of Lactobacillus acidophilus/Bifidobacterium infantis probiotics on growth in VLBWI during primary stay in hospital and (b) to determine whether this effect is modified by antibiotic exposure. In linear regression models the administration of probiotics was independently associated with improved weight gain [g/d; effect size B = 0.62 (95% CI: 0.37–0.87), p < 0.001], and higher growth rates for body length [(mm/d; B = 0.06 (95% CI: 0.04–0.08), p < 0.001] and head circumference [mm/d; B = 0.03, 95% CI: 0.02–0.04, p < 0.001]. This effect was pronounced in infants with postnatal exposure to antibiotics; i.e. weight gain [g/d; B = 0.66 (95% CI: 0.32–1), p < 0.001], growth rate body length [(mm/d; B = 0.09 (95% CI: 0.06–0.12), p < 0.001] and head circumference [mm/d; B = 0.04, 95% CI: 0.02–0.06, p < 0.001]. In the small subgroup that was available for analysis at 5-year-follow-up (with probiotics: n = 120 vs. without probiotics: n = 54) we noted a sustained effect of probiotics in infants who received postnatal antibiotics. Probiotics may improve growth in antibiotic-treated infants which needs to be confirmed in randomized-controlled trials.Christoph HärtelJulia PagelJuliane SpieglerJanne BumaPhilipp HennekeMichael ZemlinDorothee ViemannChristian GilleStephan GehringDavid FrommholdJan RuppEgbert HertingWolfgang GöpelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Christoph Härtel Julia Pagel Juliane Spiegler Janne Buma Philipp Henneke Michael Zemlin Dorothee Viemann Christian Gille Stephan Gehring David Frommhold Jan Rupp Egbert Herting Wolfgang Göpel Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics |
| description |
Abstract We performed an observational study with very-low-birth weight infants (VLBWI) ≤33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n = 8534, n = 6229 received probiotics). The primary objectives of our study were (a) to assess the effect of Lactobacillus acidophilus/Bifidobacterium infantis probiotics on growth in VLBWI during primary stay in hospital and (b) to determine whether this effect is modified by antibiotic exposure. In linear regression models the administration of probiotics was independently associated with improved weight gain [g/d; effect size B = 0.62 (95% CI: 0.37–0.87), p < 0.001], and higher growth rates for body length [(mm/d; B = 0.06 (95% CI: 0.04–0.08), p < 0.001] and head circumference [mm/d; B = 0.03, 95% CI: 0.02–0.04, p < 0.001]. This effect was pronounced in infants with postnatal exposure to antibiotics; i.e. weight gain [g/d; B = 0.66 (95% CI: 0.32–1), p < 0.001], growth rate body length [(mm/d; B = 0.09 (95% CI: 0.06–0.12), p < 0.001] and head circumference [mm/d; B = 0.04, 95% CI: 0.02–0.06, p < 0.001]. In the small subgroup that was available for analysis at 5-year-follow-up (with probiotics: n = 120 vs. without probiotics: n = 54) we noted a sustained effect of probiotics in infants who received postnatal antibiotics. Probiotics may improve growth in antibiotic-treated infants which needs to be confirmed in randomized-controlled trials. |
| format |
article |
| author |
Christoph Härtel Julia Pagel Juliane Spiegler Janne Buma Philipp Henneke Michael Zemlin Dorothee Viemann Christian Gille Stephan Gehring David Frommhold Jan Rupp Egbert Herting Wolfgang Göpel |
| author_facet |
Christoph Härtel Julia Pagel Juliane Spiegler Janne Buma Philipp Henneke Michael Zemlin Dorothee Viemann Christian Gille Stephan Gehring David Frommhold Jan Rupp Egbert Herting Wolfgang Göpel |
| author_sort |
Christoph Härtel |
| title |
Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics |
| title_short |
Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics |
| title_full |
Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics |
| title_fullStr |
Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics |
| title_full_unstemmed |
Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics |
| title_sort |
lactobacillus acidophilus/bifidobacterium infantis probiotics are associated with increased growth of vlbwi among those exposed to antibiotics |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/edfff3111e9848699499ca171dfd09c8 |
| work_keys_str_mv |
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1718394312311439360 |