The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and show antitumor activity in a mouse model of breast cancer...

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Autores principales: Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair, Anne-Sophie Journé, Sarah Gallet, Julie Dam, Avais Daulat, Delphine Ndiaye-Lobry, Olivier Lahuna, Angeliki Karamitri, Jean-Luc Guillaume, Marcio Do Cruzeiro, François Guillonneau, Anastasia Saade, Nathalie Clément, Thomas Courivaud, Nawel Kaabi, Kenjiro Tadagaki, Philippe Delagrange, Vincent Prévot, Olivier Hermine, Céline Prunier, Ralf Jockers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ee01b8e19b6d47e3a5db8a61ae00a911
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spelling oai:doaj.org-article:ee01b8e19b6d47e3a5db8a61ae00a9112021-12-02T14:39:25ZThe orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development10.1038/s41467-018-03609-x2041-1723https://doaj.org/article/ee01b8e19b6d47e3a5db8a61ae00a9112018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03609-xhttps://doaj.org/toc/2041-1723Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and show antitumor activity in a mouse model of breast cancer.Stefanie WojciechRaise AhmadZakia Belaid-ChoucairAnne-Sophie JournéSarah GalletJulie DamAvais DaulatDelphine Ndiaye-LobryOlivier LahunaAngeliki KaramitriJean-Luc GuillaumeMarcio Do CruzeiroFrançois GuillonneauAnastasia SaadeNathalie ClémentThomas CourivaudNawel KaabiKenjiro TadagakiPhilippe DelagrangeVincent PrévotOlivier HermineCéline PrunierRalf JockersNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Stefanie Wojciech
Raise Ahmad
Zakia Belaid-Choucair
Anne-Sophie Journé
Sarah Gallet
Julie Dam
Avais Daulat
Delphine Ndiaye-Lobry
Olivier Lahuna
Angeliki Karamitri
Jean-Luc Guillaume
Marcio Do Cruzeiro
François Guillonneau
Anastasia Saade
Nathalie Clément
Thomas Courivaud
Nawel Kaabi
Kenjiro Tadagaki
Philippe Delagrange
Vincent Prévot
Olivier Hermine
Céline Prunier
Ralf Jockers
The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
description Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and show antitumor activity in a mouse model of breast cancer.
format article
author Stefanie Wojciech
Raise Ahmad
Zakia Belaid-Choucair
Anne-Sophie Journé
Sarah Gallet
Julie Dam
Avais Daulat
Delphine Ndiaye-Lobry
Olivier Lahuna
Angeliki Karamitri
Jean-Luc Guillaume
Marcio Do Cruzeiro
François Guillonneau
Anastasia Saade
Nathalie Clément
Thomas Courivaud
Nawel Kaabi
Kenjiro Tadagaki
Philippe Delagrange
Vincent Prévot
Olivier Hermine
Céline Prunier
Ralf Jockers
author_facet Stefanie Wojciech
Raise Ahmad
Zakia Belaid-Choucair
Anne-Sophie Journé
Sarah Gallet
Julie Dam
Avais Daulat
Delphine Ndiaye-Lobry
Olivier Lahuna
Angeliki Karamitri
Jean-Luc Guillaume
Marcio Do Cruzeiro
François Guillonneau
Anastasia Saade
Nathalie Clément
Thomas Courivaud
Nawel Kaabi
Kenjiro Tadagaki
Philippe Delagrange
Vincent Prévot
Olivier Hermine
Céline Prunier
Ralf Jockers
author_sort Stefanie Wojciech
title The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
title_short The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
title_full The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
title_fullStr The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
title_full_unstemmed The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
title_sort orphan gpr50 receptor promotes constitutive tgfβ receptor signaling and protects against cancer development
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ee01b8e19b6d47e3a5db8a61ae00a911
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