Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction

Shiro Amano, Kenji Inoue Inouye Eye Hospital, Chiyoda-ku, Tokyo, Japan Purpose: To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD).Patients and methods: The subjects were consecutive patients diagnosed with bot...

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Auteurs principaux:	Amano S, Inoue K
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2017
Sujets:	diquafosol meibomian gland dysfunction dry eye Ophthalmology RE1-994
Accès en ligne:	https://doaj.org/article/ee06ff47e5a147e4accffcdd8a3bcd3e
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spelling	oai:doaj.org-article:ee06ff47e5a147e4accffcdd8a3bcd3e2021-12-02T08:17:21ZEffect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction1177-5483https://doaj.org/article/ee06ff47e5a147e4accffcdd8a3bcd3e2017-09-01T00:00:00Zhttps://www.dovepress.com/effect-of-topical-3-diquafosol-sodium-on-eyes-with-dry-eye-disease-and-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Shiro Amano, Kenji Inoue Inouye Eye Hospital, Chiyoda-ku, Tokyo, Japan Purpose: To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD).Patients and methods: The subjects were consecutive patients diagnosed with both DED and MGD at Inouye Eye Hospital between March and September of 2016. The subjects were administered topical 3% diquafosol sodium ophthalmic solution six times a day for 3 months. At each study visit, subjects underwent slit-lamp examination and completed MGD symptoms and dry eye-related quality of life score (DEQS) questionnaires. Meibum quality (meibum score) and meibomian gland loss (meiboscore) were evaluated. Tear lipid layer thickness was measured in both eyes with an ocular surface interferometer immediately after clinic arrival and 20 minutes after instillation of one drop of topical diquafosol.Results: Thirteen patients (3 men, 10 women) with a mean age of 69.5±8.3 years completed the 3-month study. The number of telangiectasia and plugged meibomian gland orifices significantly decreased from baseline after 1 month of diquafosol use. The meibum score and the meiboscore significantly decreased from baseline at 3 months. Also, the lipid layer thickness was greater after diquafosol administration than before administration at baseline and 1, 2, and 3 months by 12.2, 11.5, 9.5, and 17.0 nm, respectively, but this difference was only significant at 3 months (p=0.039). The DEQS ocular symptom (p=0.065) and MGD questionnaire (p=0.081) scores tended to be lower than baseline at 3 months.Conclusion: Diquafosol sodium ophthalmic solution improves DED- and MGD-related signs in eyes with MGD. Keywords: diquafosol, meibomian gland dysfunction, dry eye Amano SInoue KDove Medical Pressarticlediquafosolmeibomian gland dysfunctiondry eyeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1677-1682 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	diquafosol meibomian gland dysfunction dry eye Ophthalmology RE1-994
spellingShingle	diquafosol meibomian gland dysfunction dry eye Ophthalmology RE1-994 Amano S Inoue K Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction
description	Shiro Amano, Kenji Inoue Inouye Eye Hospital, Chiyoda-ku, Tokyo, Japan Purpose: To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD).Patients and methods: The subjects were consecutive patients diagnosed with both DED and MGD at Inouye Eye Hospital between March and September of 2016. The subjects were administered topical 3% diquafosol sodium ophthalmic solution six times a day for 3 months. At each study visit, subjects underwent slit-lamp examination and completed MGD symptoms and dry eye-related quality of life score (DEQS) questionnaires. Meibum quality (meibum score) and meibomian gland loss (meiboscore) were evaluated. Tear lipid layer thickness was measured in both eyes with an ocular surface interferometer immediately after clinic arrival and 20 minutes after instillation of one drop of topical diquafosol.Results: Thirteen patients (3 men, 10 women) with a mean age of 69.5±8.3 years completed the 3-month study. The number of telangiectasia and plugged meibomian gland orifices significantly decreased from baseline after 1 month of diquafosol use. The meibum score and the meiboscore significantly decreased from baseline at 3 months. Also, the lipid layer thickness was greater after diquafosol administration than before administration at baseline and 1, 2, and 3 months by 12.2, 11.5, 9.5, and 17.0 nm, respectively, but this difference was only significant at 3 months (p=0.039). The DEQS ocular symptom (p=0.065) and MGD questionnaire (p=0.081) scores tended to be lower than baseline at 3 months.Conclusion: Diquafosol sodium ophthalmic solution improves DED- and MGD-related signs in eyes with MGD. Keywords: diquafosol, meibomian gland dysfunction, dry eye
format	article
author	Amano S Inoue K
author_facet	Amano S Inoue K
author_sort	Amano S
title	Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction
title_short	Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction
title_full	Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction
title_fullStr	Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction
title_full_unstemmed	Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction
title_sort	effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ee06ff47e5a147e4accffcdd8a3bcd3e
work_keys_str_mv	AT amanos effectoftopical3diquafosolsodiumoneyeswithdryeyediseaseandmeibomianglanddysfunction AT inouek effectoftopical3diquafosolsodiumoneyeswithdryeyediseaseandmeibomianglanddysfunction
_version_	1718398637800685568

Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction

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