Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3

Abstract Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks were injected unilaterally with adeno-associated...

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Bibliographic Details
Main Authors: Ken Hashimoto, Tyler T. Hickman, Jun Suzuki, Lingchao Ji, David C. Kohrman, Gabriel Corfas, M. Charles Liberman
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
R
Q
Online Access:https://doaj.org/article/ee0860e21d1648468a10153d8c2a20c3
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