Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3
Abstract Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks were injected unilaterally with adeno-associated...
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| Main Authors: | Ken Hashimoto, Tyler T. Hickman, Jun Suzuki, Lingchao Ji, David C. Kohrman, Gabriel Corfas, M. Charles Liberman |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2019
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| Subjects: | |
| Online Access: | https://doaj.org/article/ee0860e21d1648468a10153d8c2a20c3 |
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