DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers

Abstract This study was conducted to explore the effects of DNMT1 and DNMT3A polymorphisms on susceptibility to noise-induced hearing loss (NIHL) in Chinese workers. A total of 2689 industrial workers from a single textile factory were recruited. Venous blood was collected, as were questionnaire and...

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Autores principales:	Enmin Ding, Jing Liu, Haoran Guo, Huanxi Shen, Hengdong Zhang, Wei Gong, Haiyan Song, Baoli Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Noise-induced Hearing Loss (NIHL) DNA Methyltransferase (DNMT1) DNMT3A Gene AGG Haplotype Single Nucleotide Polymorphisms (SNPs) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee0997c79666449196e6aeb9ecd5f54d
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spelling	oai:doaj.org-article:ee0997c79666449196e6aeb9ecd5f54d2021-12-02T11:41:13ZDNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers10.1038/s41598-018-29648-42045-2322https://doaj.org/article/ee0997c79666449196e6aeb9ecd5f54d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29648-4https://doaj.org/toc/2045-2322Abstract This study was conducted to explore the effects of DNMT1 and DNMT3A polymorphisms on susceptibility to noise-induced hearing loss (NIHL) in Chinese workers. A total of 2689 industrial workers from a single textile factory were recruited. Venous blood was collected, as were questionnaire and pure-tone audiometry (PTA) data by specialist physicians. Four selected SNPs (rs7578575, rs749131, rs1550117, and rs2228611) in DNMT1 and DNMT3A were genotyped in 527 NIHL patients and 527 controls. Then, main effects of the genotypes and their interactions were evaluated. Results revealed that the GG genotype at rs749131 and the AG/GG genotypes at rs1550117 and rs2228611 [odds ratio (OR) = 1.87, 2.57, and 1.98 respectively], as well as the haplotypes AGGG and TGGA (rs7578578-rs749131-rs1550117-rs2228611) (OR = 1.35 and 1.56, respectively) were associated with an increased risk of NIHL in the Chinese population. Multifactor dimensionality reduction analysis indicated that rs7578575, rs749131, and rs2228611 interact and are related to increased NIHL risk (OR = 1.63). The genetic polymorphisms rs749131 G, rs1550117 G, and rs2228611 G within the DNMT1 and DNMT3A genes are associated with an increased risk of NIHL in the Chinese population and have the potential to act as biomarkers for noise-exposed workers.Enmin DingJing LiuHaoran GuoHuanxi ShenHengdong ZhangWei GongHaiyan SongBaoli ZhuNature PortfolioarticleNoise-induced Hearing Loss (NIHL)DNA Methyltransferase (DNMT1)DNMT3A GeneAGG HaplotypeSingle Nucleotide Polymorphisms (SNPs)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Noise-induced Hearing Loss (NIHL) DNA Methyltransferase (DNMT1) DNMT3A Gene AGG Haplotype Single Nucleotide Polymorphisms (SNPs) Medicine R Science Q
spellingShingle	Noise-induced Hearing Loss (NIHL) DNA Methyltransferase (DNMT1) DNMT3A Gene AGG Haplotype Single Nucleotide Polymorphisms (SNPs) Medicine R Science Q Enmin Ding Jing Liu Haoran Guo Huanxi Shen Hengdong Zhang Wei Gong Haiyan Song Baoli Zhu DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
description	Abstract This study was conducted to explore the effects of DNMT1 and DNMT3A polymorphisms on susceptibility to noise-induced hearing loss (NIHL) in Chinese workers. A total of 2689 industrial workers from a single textile factory were recruited. Venous blood was collected, as were questionnaire and pure-tone audiometry (PTA) data by specialist physicians. Four selected SNPs (rs7578575, rs749131, rs1550117, and rs2228611) in DNMT1 and DNMT3A were genotyped in 527 NIHL patients and 527 controls. Then, main effects of the genotypes and their interactions were evaluated. Results revealed that the GG genotype at rs749131 and the AG/GG genotypes at rs1550117 and rs2228611 [odds ratio (OR) = 1.87, 2.57, and 1.98 respectively], as well as the haplotypes AGGG and TGGA (rs7578578-rs749131-rs1550117-rs2228611) (OR = 1.35 and 1.56, respectively) were associated with an increased risk of NIHL in the Chinese population. Multifactor dimensionality reduction analysis indicated that rs7578575, rs749131, and rs2228611 interact and are related to increased NIHL risk (OR = 1.63). The genetic polymorphisms rs749131 G, rs1550117 G, and rs2228611 G within the DNMT1 and DNMT3A genes are associated with an increased risk of NIHL in the Chinese population and have the potential to act as biomarkers for noise-exposed workers.
format	article
author	Enmin Ding Jing Liu Haoran Guo Huanxi Shen Hengdong Zhang Wei Gong Haiyan Song Baoli Zhu
author_facet	Enmin Ding Jing Liu Haoran Guo Huanxi Shen Hengdong Zhang Wei Gong Haiyan Song Baoli Zhu
author_sort	Enmin Ding
title	DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
title_short	DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
title_full	DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
title_fullStr	DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
title_full_unstemmed	DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers
title_sort	dnmt1 and dnmt3a haplotypes associated with noise-induced hearing loss in chinese workers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ee0997c79666449196e6aeb9ecd5f54d
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DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers

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