Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin.

Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin.

Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in...

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Autores principales: Luís Martins, Diana Fernández-Mallo, Marta G Novelle, María J Vázquez, Manuel Tena-Sempere, Rubén Nogueiras, Miguel López, Carlos Diéguez
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ee0d34b46e7b4b5c856607bd07fa97d9
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