The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study

Introduction. Epidural fibrosis is an urgent problem in modern spinal surgery and orthopedics. The formation of connective tissue in the epidural space after performing surgical interventions on the spinal column inevitably leads to adhesion of the latter to the dura mater and compression of neural...

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Autores principales:	K. Ts. Erdyneev, V. A. Sorokovikov, D. N. Sambuev, V. P. Saganov, B. B. Dambaev, S. N. Larionov, O. A. Goldberg, S. A. Lepekhova, I. A. Stepanov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	epidural fibrosis prevention spatially cross-linked polymer application Science Q
Acceso en línea:	https://doaj.org/article/ee1368ef9a5049868772e2e10700b8d0
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spelling	oai:doaj.org-article:ee1368ef9a5049868772e2e10700b8d02021-11-23T06:14:46ZThe effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study2541-94202587-959610.29413/ABS.2021-6.3.18https://doaj.org/article/ee1368ef9a5049868772e2e10700b8d02021-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2863https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Introduction. Epidural fibrosis is an urgent problem in modern spinal surgery and orthopedics. The formation of connective tissue in the epidural space after performing surgical interventions on the spinal column inevitably leads to adhesion of the latter to the dura mater and compression of neural structures, followed by the formation of clinical and neurological symptoms. The search for literary sources in domestic and foreign scientific databases has demonstrated the presence of several works studying the effectiveness of barrier methods for preventing the development of epidural fibrosis. It should be noted that the results of these studies are ambiguous and largely contradictory.The purpose was to study the effectiveness of using a spatially cross-linked polymer in the postoperative lumbar epidural fibrosis prevention in an experiment.Materials and methods. The study included 26 male Wistar rats (average body weight 338.5±9.07 g), which were divided into two groups: Group I (control, n = 12): animals underwent laminectomy at the level of vertebral bodies LVII – SI without application of spatially crosslinked polymer; Group II (experimental, n = 14): animals underwent laminectomy at the level of vertebral bodies LVII – SI followed by application of a spatially cross-linked polymer to the dura mater. The morphological and instrumental parameters were studied.Results. Significant differences were noted in the severity of epidural fibrosis (χ2 = 14.846, p = 0.003), the number of newly formed vessels (F = 14.371, p<0.001), the number of fibroblasts (F = 11.158, p<0.001), as well as in the severity of vertebral stenosis channe l according to multislice computed tomography (χ2 = 17.207, p=0.002) between the control and experimental groups of animals.Conclusion. Application of a spatially cross-linked polymer to the dura mater is an effective way to prevent the development of postoperative epidural fibrosis.K. Ts. ErdyneevV. A. SorokovikovD. N. SambuevV. P. SaganovB. B. DambaevS. N. LarionovO. A. GoldbergS. A. LepekhovaI. A. StepanovScientific Сentre for Family Health and Human Reproduction Problemsarticleepidural fibrosispreventionspatially cross-linked polymerapplicationScienceQRUActa Biomedica Scientifica, Vol 6, Iss 3, Pp 174-184 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	epidural fibrosis prevention spatially cross-linked polymer application Science Q
spellingShingle	epidural fibrosis prevention spatially cross-linked polymer application Science Q K. Ts. Erdyneev V. A. Sorokovikov D. N. Sambuev V. P. Saganov B. B. Dambaev S. N. Larionov O. A. Goldberg S. A. Lepekhova I. A. Stepanov The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study
description	Introduction. Epidural fibrosis is an urgent problem in modern spinal surgery and orthopedics. The formation of connective tissue in the epidural space after performing surgical interventions on the spinal column inevitably leads to adhesion of the latter to the dura mater and compression of neural structures, followed by the formation of clinical and neurological symptoms. The search for literary sources in domestic and foreign scientific databases has demonstrated the presence of several works studying the effectiveness of barrier methods for preventing the development of epidural fibrosis. It should be noted that the results of these studies are ambiguous and largely contradictory.The purpose was to study the effectiveness of using a spatially cross-linked polymer in the postoperative lumbar epidural fibrosis prevention in an experiment.Materials and methods. The study included 26 male Wistar rats (average body weight 338.5±9.07 g), which were divided into two groups: Group I (control, n = 12): animals underwent laminectomy at the level of vertebral bodies LVII – SI without application of spatially crosslinked polymer; Group II (experimental, n = 14): animals underwent laminectomy at the level of vertebral bodies LVII – SI followed by application of a spatially cross-linked polymer to the dura mater. The morphological and instrumental parameters were studied.Results. Significant differences were noted in the severity of epidural fibrosis (χ2 = 14.846, p = 0.003), the number of newly formed vessels (F = 14.371, p<0.001), the number of fibroblasts (F = 11.158, p<0.001), as well as in the severity of vertebral stenosis channe l according to multislice computed tomography (χ2 = 17.207, p=0.002) between the control and experimental groups of animals.Conclusion. Application of a spatially cross-linked polymer to the dura mater is an effective way to prevent the development of postoperative epidural fibrosis.
format	article
author	K. Ts. Erdyneev V. A. Sorokovikov D. N. Sambuev V. P. Saganov B. B. Dambaev S. N. Larionov O. A. Goldberg S. A. Lepekhova I. A. Stepanov
author_facet	K. Ts. Erdyneev V. A. Sorokovikov D. N. Sambuev V. P. Saganov B. B. Dambaev S. N. Larionov O. A. Goldberg S. A. Lepekhova I. A. Stepanov
author_sort	K. Ts. Erdyneev
title	The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study
title_short	The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study
title_full	The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study
title_fullStr	The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study
title_full_unstemmed	The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study
title_sort	effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/ee1368ef9a5049868772e2e10700b8d0
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The effectiveness of spatially cross-linked polymer in the postoperative epidural fibrosis prevention: an experimental study

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