An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases

Some of the most fundamental influences of microorganisms inhabiting the human intestinal tract are exerted during infant development and impact the maturation of intestinal mucosa and gut immune system. The impact of bacteria on the host gut immune system is partially mediated via released extracel...

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Autor principal:	Rafał Filip
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	extracellular vesicles gut maturation necrotizing enterocolitis inflammatory bowel disease Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ee16c3c70a3942ac9f807cf075dcf650
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spelling	oai:doaj.org-article:ee16c3c70a3942ac9f807cf075dcf6502021-11-25T17:12:49ZAn Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases10.3390/cells101132022073-4409https://doaj.org/article/ee16c3c70a3942ac9f807cf075dcf6502021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3202https://doaj.org/toc/2073-4409Some of the most fundamental influences of microorganisms inhabiting the human intestinal tract are exerted during infant development and impact the maturation of intestinal mucosa and gut immune system. The impact of bacteria on the host gut immune system is partially mediated via released extracellular vesicles (EVs). The heterogeneity in EV content, size, and bacterial species origin can have an impact on intestinal cells, resulting in inflammation and an immune response, or facilitate pathogen entry into the gut wall. In mammals, maintaining the integrity of the gut barrier might also be an evolutionary function of maternal milk EVs. Recently, the usage of EVs has been explored as a novel therapeutic approach in several pathological conditions, including necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD). In this review, we attempt to summarize the current knowledge of EV biology, followed by a discussion of the role that EVs play in gut maturation and the pathogenesis of NEC and IBD.Rafał FilipMDPI AGarticleextracellular vesiclesgut maturationnecrotizing enterocolitisinflammatory bowel diseaseBiology (General)QH301-705.5ENCells, Vol 10, Iss 3202, p 3202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular vesicles gut maturation necrotizing enterocolitis inflammatory bowel disease Biology (General) QH301-705.5
spellingShingle	extracellular vesicles gut maturation necrotizing enterocolitis inflammatory bowel disease Biology (General) QH301-705.5 Rafał Filip An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases
description	Some of the most fundamental influences of microorganisms inhabiting the human intestinal tract are exerted during infant development and impact the maturation of intestinal mucosa and gut immune system. The impact of bacteria on the host gut immune system is partially mediated via released extracellular vesicles (EVs). The heterogeneity in EV content, size, and bacterial species origin can have an impact on intestinal cells, resulting in inflammation and an immune response, or facilitate pathogen entry into the gut wall. In mammals, maintaining the integrity of the gut barrier might also be an evolutionary function of maternal milk EVs. Recently, the usage of EVs has been explored as a novel therapeutic approach in several pathological conditions, including necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD). In this review, we attempt to summarize the current knowledge of EV biology, followed by a discussion of the role that EVs play in gut maturation and the pathogenesis of NEC and IBD.
format	article
author	Rafał Filip
author_facet	Rafał Filip
author_sort	Rafał Filip
title	An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases
title_short	An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases
title_full	An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases
title_fullStr	An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases
title_full_unstemmed	An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases
title_sort	update on the role of extracellular vesicles in the pathogenesis of necrotizing enterocolitis and inflammatory bowel diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ee16c3c70a3942ac9f807cf075dcf650
work_keys_str_mv	AT rafałfilip anupdateontheroleofextracellularvesiclesinthepathogenesisofnecrotizingenterocolitisandinflammatoryboweldiseases AT rafałfilip updateontheroleofextracellularvesiclesinthepathogenesisofnecrotizingenterocolitisandinflammatoryboweldiseases
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An Update on the Role of Extracellular Vesicles in the Pathogenesis of Necrotizing Enterocolitis and Inflammatory Bowel Diseases

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