Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.

Although amnestic mild cognitive impairment (aMCI; often considered a prodromal phase of Alzheimer's disease, AD) is most recognized by its implications for decline in memory function, research suggests that deficits in attention are present early in aMCI and may be predictive of progression to...

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Autores principales:	Nicholas T Van Dam, Mary Sano, Effie M Mitsis, Hillel T Grossman, Xiaosi Gu, Yunsoo Park, Patrick R Hof, Jin Fan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee19743ebc284b9c8c6734fb6c5ebe73
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spelling	oai:doaj.org-article:ee19743ebc284b9c8c6734fb6c5ebe732021-11-18T08:01:45ZFunctional neural correlates of attentional deficits in amnestic mild cognitive impairment.1932-620310.1371/journal.pone.0054035https://doaj.org/article/ee19743ebc284b9c8c6734fb6c5ebe732013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23326568/?tool=EBIhttps://doaj.org/toc/1932-6203Although amnestic mild cognitive impairment (aMCI; often considered a prodromal phase of Alzheimer's disease, AD) is most recognized by its implications for decline in memory function, research suggests that deficits in attention are present early in aMCI and may be predictive of progression to AD. The present study used functional magnetic resonance imaging to examine differences in the brain during the attention network test between 8 individuals with aMCI and 8 neurologically healthy, demographically matched controls. While there were no significant behavioral differences between groups for the alerting and orienting functions, patients with aMCI showed more activity in neural regions typically associated with the networks subserving these functions (e.g., temporoparietal junction and posterior parietal regions, respectively). More importantly, there were both behavioral (i.e., greater conflict effect) and corresponding neural deficits in executive control (e.g., less activation in the prefrontal and anterior cingulate cortices). Although based on a small number of patients, our findings suggest that deficits of attention, especially the executive control of attention, may significantly contribute to the behavioral and cognitive deficits of aMCI.Nicholas T Van DamMary SanoEffie M MitsisHillel T GrossmanXiaosi GuYunsoo ParkPatrick R HofJin FanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54035 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicholas T Van Dam Mary Sano Effie M Mitsis Hillel T Grossman Xiaosi Gu Yunsoo Park Patrick R Hof Jin Fan Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.
description	Although amnestic mild cognitive impairment (aMCI; often considered a prodromal phase of Alzheimer's disease, AD) is most recognized by its implications for decline in memory function, research suggests that deficits in attention are present early in aMCI and may be predictive of progression to AD. The present study used functional magnetic resonance imaging to examine differences in the brain during the attention network test between 8 individuals with aMCI and 8 neurologically healthy, demographically matched controls. While there were no significant behavioral differences between groups for the alerting and orienting functions, patients with aMCI showed more activity in neural regions typically associated with the networks subserving these functions (e.g., temporoparietal junction and posterior parietal regions, respectively). More importantly, there were both behavioral (i.e., greater conflict effect) and corresponding neural deficits in executive control (e.g., less activation in the prefrontal and anterior cingulate cortices). Although based on a small number of patients, our findings suggest that deficits of attention, especially the executive control of attention, may significantly contribute to the behavioral and cognitive deficits of aMCI.
format	article
author	Nicholas T Van Dam Mary Sano Effie M Mitsis Hillel T Grossman Xiaosi Gu Yunsoo Park Patrick R Hof Jin Fan
author_facet	Nicholas T Van Dam Mary Sano Effie M Mitsis Hillel T Grossman Xiaosi Gu Yunsoo Park Patrick R Hof Jin Fan
author_sort	Nicholas T Van Dam
title	Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.
title_short	Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.
title_full	Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.
title_fullStr	Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.
title_full_unstemmed	Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.
title_sort	functional neural correlates of attentional deficits in amnestic mild cognitive impairment.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ee19743ebc284b9c8c6734fb6c5ebe73
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Functional neural correlates of attentional deficits in amnestic mild cognitive impairment.

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