AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN

Abstract. Age dynamics of humoral immunity was studied in healthy children, i.e., 11 newborns, 33 infants of 4 to 8 months, 32 children of 1 to 2 years old,, 17 children of 4 to 5 years old, 25 children of 6 to 8 years old, 15 children of 9 to 11 years old, and 28 adolescents of 14 to 16 years old....

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Autores principales:	A. P. Toptygina, E. L. Semikina, E. A. Kopyltsova, V. A. Alyoshkin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	b1 cells b2 cells b-cell memory igg subclasses Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ee19f56a61ef4a7b9232de58a969f8d8
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id	oai:doaj.org-article:ee19f56a61ef4a7b9232de58a969f8d8
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spelling	oai:doaj.org-article:ee19f56a61ef4a7b9232de58a969f8d82021-11-18T08:03:41ZAGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN1563-06252313-741X10.15789/1563-0625-2012-4-5-289-294https://doaj.org/article/ee19f56a61ef4a7b9232de58a969f8d82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/530https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Age dynamics of humoral immunity was studied in healthy children, i.e., 11 newborns, 33 infants of 4 to 8 months, 32 children of 1 to 2 years old,, 17 children of 4 to 5 years old, 25 children of 6 to 8 years old, 15 children of 9 to 11 years old, and 28 adolescents of 14 to 16 years old. Evaluation of membrane receptors on B cells was performed by means of three-colour fluorescent label and allowed of characterizing B1 subpopulations (CD19+CD5+CD27-), naпve B2 cells (CD19+CD5-CD27-), and B2 memory cells (CD19+CD5-CD27+). B1 cells have been shown to dominate in blood of newborns and younger children (up to 5 years old). By the contrary, B2 memory cells were nearly undetectable in newborns, and exceeded 20% in adolescents (by 15 years old). Meanwhile, it has been revealed that the amounts of IgG1 and IgG3 subclasses did progressively increase with age, whereas IgG2 remained decreased to 50% of adult values for a long time, and reached them by 11 years and later. We suggest that the age dynamics of IgG subclasses is connected with age-dependent changes in B cell subpopulations.A. P. ToptyginaE. L. SemikinaE. A. KopyltsovaV. A. AlyoshkinSPb RAACIarticleb1 cellsb2 cellsb-cell memoryigg subclassesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 289-294 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	b1 cells b2 cells b-cell memory igg subclasses Immunologic diseases. Allergy RC581-607
spellingShingle	b1 cells b2 cells b-cell memory igg subclasses Immunologic diseases. Allergy RC581-607 A. P. Toptygina E. L. Semikina E. A. Kopyltsova V. A. Alyoshkin AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN
description	Abstract. Age dynamics of humoral immunity was studied in healthy children, i.e., 11 newborns, 33 infants of 4 to 8 months, 32 children of 1 to 2 years old,, 17 children of 4 to 5 years old, 25 children of 6 to 8 years old, 15 children of 9 to 11 years old, and 28 adolescents of 14 to 16 years old. Evaluation of membrane receptors on B cells was performed by means of three-colour fluorescent label and allowed of characterizing B1 subpopulations (CD19+CD5+CD27-), naпve B2 cells (CD19+CD5-CD27-), and B2 memory cells (CD19+CD5-CD27+). B1 cells have been shown to dominate in blood of newborns and younger children (up to 5 years old). By the contrary, B2 memory cells were nearly undetectable in newborns, and exceeded 20% in adolescents (by 15 years old). Meanwhile, it has been revealed that the amounts of IgG1 and IgG3 subclasses did progressively increase with age, whereas IgG2 remained decreased to 50% of adult values for a long time, and reached them by 11 years and later. We suggest that the age dynamics of IgG subclasses is connected with age-dependent changes in B cell subpopulations.
format	article
author	A. P. Toptygina E. L. Semikina E. A. Kopyltsova V. A. Alyoshkin
author_facet	A. P. Toptygina E. L. Semikina E. A. Kopyltsova V. A. Alyoshkin
author_sort	A. P. Toptygina
title	AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN
title_short	AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN
title_full	AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN
title_fullStr	AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN
title_full_unstemmed	AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN
title_sort	age-dependent features of evolving humoral immunity in children
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ee19f56a61ef4a7b9232de58a969f8d8
work_keys_str_mv	AT aptoptygina agedependentfeaturesofevolvinghumoralimmunityinchildren AT elsemikina agedependentfeaturesofevolvinghumoralimmunityinchildren AT eakopyltsova agedependentfeaturesofevolvinghumoralimmunityinchildren AT vaalyoshkin agedependentfeaturesofevolvinghumoralimmunityinchildren
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AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN

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