Application of diphenydramine ointment to the eyelids for allergic conjunctivitis

Introduction: Allergic conjunctivitis is treated with oral anti-allergy agents or topical eye drops, but the response is often incomplete, and symptoms persist. We considered that topical treatment with an antihistamine ointment (diphenhydramine-Restamin Cream®) on the eyelids could be effective as...

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Autores principales:	Mitsuhiro Kamimura, Takako Ohnishi, Hisao Terada, Atsuto Mouri, Takahiro Naoi, Hiroaki Todo, Kenji Sugibayashi
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2021
Materias:	allergic conjunctivitis antihistamines asthma conjunctiva topical administration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ee1ff778b733497bafa191723393707a
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spelling	oai:doaj.org-article:ee1ff778b733497bafa191723393707a2021-12-02T19:14:49ZApplication of diphenydramine ointment to the eyelids for allergic conjunctivitis10.5281/zenodo.46327622695-5075https://doaj.org/article/ee1ff778b733497bafa191723393707a2021-01-01T00:00:00Zhttps://doi.org/10.5281/zenodo.4632762https://doaj.org/toc/2695-5075Introduction: Allergic conjunctivitis is treated with oral anti-allergy agents or topical eye drops, but the response is often incomplete, and symptoms persist. We considered that topical treatment with an antihistamine ointment (diphenhydramine-Restamin Cream®) on the eyelids could be effective as supplemental therapy. This study investigates the efficacy and safety of Restamin Cream® for allergic conjunctivitis. Methods: In patients with allergic conjunctivitis, Restamin Cream® was applied to both eyelids twice a day for 2 weeks. There was a 2-week observation period before treatment and a 2-week washout period after treatment. Patients recorded symptoms (eye itching and watering) on a visual analogue scale for the entire 6-week period. Assessment of quality of life, evaluation of conjunctivitis, and measurement of visual acuity and intraocular pressure were conducted at the start of observation, at initiation of treatment, at completion of treatment, and at the end of washout. Results: 7 patients were enrolled; 5 completed the study and 2 discontinued due to adverse reactions. The quality of life score and objective ocular findings improved in all 5 patients. Visual analogue scale scores for itching and watering also improved significantly in 3 and 2 patients, respectively. Adverse reactions included local skin irritation in 3/7 patients, and transient blurred vision and eye pain in 1 patient each. There were no changes of visual acuity or intraocular pressure. Conclusions: Application of diphenhydramine ointment to the eyelids was effective for allergic conjunctivitis.Mitsuhiro KamimuraTakako OhnishiHisao TeradaAtsuto MouriTakahiro NaoiHiroaki TodoKenji SugibayashiEmergency Department of Hospital San Pedro (Logroño, Spain)articleallergicconjunctivitisantihistaminesasthmaconjunctivatopical administrationMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 3, Iss 1, Pp 44-50 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	allergic conjunctivitis antihistamines asthma conjunctiva topical administration Medicine (General) R5-920
spellingShingle	allergic conjunctivitis antihistamines asthma conjunctiva topical administration Medicine (General) R5-920 Mitsuhiro Kamimura Takako Ohnishi Hisao Terada Atsuto Mouri Takahiro Naoi Hiroaki Todo Kenji Sugibayashi Application of diphenydramine ointment to the eyelids for allergic conjunctivitis
description	Introduction: Allergic conjunctivitis is treated with oral anti-allergy agents or topical eye drops, but the response is often incomplete, and symptoms persist. We considered that topical treatment with an antihistamine ointment (diphenhydramine-Restamin Cream®) on the eyelids could be effective as supplemental therapy. This study investigates the efficacy and safety of Restamin Cream® for allergic conjunctivitis. Methods: In patients with allergic conjunctivitis, Restamin Cream® was applied to both eyelids twice a day for 2 weeks. There was a 2-week observation period before treatment and a 2-week washout period after treatment. Patients recorded symptoms (eye itching and watering) on a visual analogue scale for the entire 6-week period. Assessment of quality of life, evaluation of conjunctivitis, and measurement of visual acuity and intraocular pressure were conducted at the start of observation, at initiation of treatment, at completion of treatment, and at the end of washout. Results: 7 patients were enrolled; 5 completed the study and 2 discontinued due to adverse reactions. The quality of life score and objective ocular findings improved in all 5 patients. Visual analogue scale scores for itching and watering also improved significantly in 3 and 2 patients, respectively. Adverse reactions included local skin irritation in 3/7 patients, and transient blurred vision and eye pain in 1 patient each. There were no changes of visual acuity or intraocular pressure. Conclusions: Application of diphenhydramine ointment to the eyelids was effective for allergic conjunctivitis.
format	article
author	Mitsuhiro Kamimura Takako Ohnishi Hisao Terada Atsuto Mouri Takahiro Naoi Hiroaki Todo Kenji Sugibayashi
author_facet	Mitsuhiro Kamimura Takako Ohnishi Hisao Terada Atsuto Mouri Takahiro Naoi Hiroaki Todo Kenji Sugibayashi
author_sort	Mitsuhiro Kamimura
title	Application of diphenydramine ointment to the eyelids for allergic conjunctivitis
title_short	Application of diphenydramine ointment to the eyelids for allergic conjunctivitis
title_full	Application of diphenydramine ointment to the eyelids for allergic conjunctivitis
title_fullStr	Application of diphenydramine ointment to the eyelids for allergic conjunctivitis
title_full_unstemmed	Application of diphenydramine ointment to the eyelids for allergic conjunctivitis
title_sort	application of diphenydramine ointment to the eyelids for allergic conjunctivitis
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2021
url	https://doaj.org/article/ee1ff778b733497bafa191723393707a
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Application of diphenydramine ointment to the eyelids for allergic conjunctivitis

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