Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.

<h4>Objective</h4>Flotillin gene is known as a tumor promoter or suppressor, depending on the tumor type or tumor stage. We aimed to investigate the clinical significance of flotillin2 protein expression in gastric cancer.<h4>Methods</h4>We examined flotillin2 and erbB2 level...

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Autores principales:	Zhi Zhu, Jinou Wang, Zhe Sun, Xuren Sun, Zhenning Wang, Huimian Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee22e8afb6c94bf6a530be6c380fe56f
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spelling	oai:doaj.org-article:ee22e8afb6c94bf6a530be6c380fe56f2021-11-18T07:47:03ZFlotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.1932-620310.1371/journal.pone.0062365https://doaj.org/article/ee22e8afb6c94bf6a530be6c380fe56f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23658725/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Flotillin gene is known as a tumor promoter or suppressor, depending on the tumor type or tumor stage. We aimed to investigate the clinical significance of flotillin2 protein expression in gastric cancer.<h4>Methods</h4>We examined flotillin2 and erbB2 levels in tissue microarray of 282 gastric cancer samples and analyzed the association between flotillin2 levels, clinicopathologic factors and prognosis. The regulation of erbB2 by flotillin2 was examined with flotillin2 siRNA-transfected gastric cancer cells.<h4>Results</h4>Flotillin2 partially co-localized with erbB2 at the plasma membrane as detected by confocal microscopy, levels of erbB2 were reduced after flotillin knockdown in SGC-7901 cancer cells, and the expression of flotillin2 was positively correlated with that of erbB2. In non-neoplastic gastric mucosa, flotillin2 was not expressed in the epithelial compartment. In gastric cancer, positive staining of flotillin2 was shown in 129 (45.7%) of 282 cases, also, it was significantly associated with a Lauren grade, histologic type, lymphovascular invasion and tumor location. Moreover, survival analysis showed that flotillin2 expression was an independent prognostic factor of poor survival (p<0.001).<h4>Conclusions</h4>These results indicate that a positive correlation exists between flotillin2 and erbB2 expression levels, flotillin2 maybe involved in the stabilization of erbB2 at the plasma membrane, flotillin2 is significantly correlated with cancer progression and poor prognosis in gastric cancer.Zhi ZhuJinou WangZhe SunXuren SunZhenning WangHuimian XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e62365 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhi Zhu Jinou Wang Zhe Sun Xuren Sun Zhenning Wang Huimian Xu Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.
description	<h4>Objective</h4>Flotillin gene is known as a tumor promoter or suppressor, depending on the tumor type or tumor stage. We aimed to investigate the clinical significance of flotillin2 protein expression in gastric cancer.<h4>Methods</h4>We examined flotillin2 and erbB2 levels in tissue microarray of 282 gastric cancer samples and analyzed the association between flotillin2 levels, clinicopathologic factors and prognosis. The regulation of erbB2 by flotillin2 was examined with flotillin2 siRNA-transfected gastric cancer cells.<h4>Results</h4>Flotillin2 partially co-localized with erbB2 at the plasma membrane as detected by confocal microscopy, levels of erbB2 were reduced after flotillin knockdown in SGC-7901 cancer cells, and the expression of flotillin2 was positively correlated with that of erbB2. In non-neoplastic gastric mucosa, flotillin2 was not expressed in the epithelial compartment. In gastric cancer, positive staining of flotillin2 was shown in 129 (45.7%) of 282 cases, also, it was significantly associated with a Lauren grade, histologic type, lymphovascular invasion and tumor location. Moreover, survival analysis showed that flotillin2 expression was an independent prognostic factor of poor survival (p<0.001).<h4>Conclusions</h4>These results indicate that a positive correlation exists between flotillin2 and erbB2 expression levels, flotillin2 maybe involved in the stabilization of erbB2 at the plasma membrane, flotillin2 is significantly correlated with cancer progression and poor prognosis in gastric cancer.
format	article
author	Zhi Zhu Jinou Wang Zhe Sun Xuren Sun Zhenning Wang Huimian Xu
author_facet	Zhi Zhu Jinou Wang Zhe Sun Xuren Sun Zhenning Wang Huimian Xu
author_sort	Zhi Zhu
title	Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.
title_short	Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.
title_full	Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.
title_fullStr	Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.
title_full_unstemmed	Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.
title_sort	flotillin2 expression correlates with her2 levels and poor prognosis in gastric cancer.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ee22e8afb6c94bf6a530be6c380fe56f
work_keys_str_mv	AT zhizhu flotillin2expressioncorrelateswithher2levelsandpoorprognosisingastriccancer AT jinouwang flotillin2expressioncorrelateswithher2levelsandpoorprognosisingastriccancer AT zhesun flotillin2expressioncorrelateswithher2levelsandpoorprognosisingastriccancer AT xurensun flotillin2expressioncorrelateswithher2levelsandpoorprognosisingastriccancer AT zhenningwang flotillin2expressioncorrelateswithher2levelsandpoorprognosisingastriccancer AT huimianxu flotillin2expressioncorrelateswithher2levelsandpoorprognosisingastriccancer
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Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.

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