Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening

Flow reactors have applications in reaction screening and optimisation, but typically operate in linear or radial configurations. Here a bench-top parallel flow synthesiser which distributes reagents between sixteen microreactors allows for rapid optimisation of chemical libraries, with uniform flow...

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Autores principales:	Gwang-Noh Ahn, Brijesh M. Sharma, Santosh Lahore, Se-Jun Yim, Shinde Vidyacharan, Dong-Pyo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ee235b33cb264e23897263c85e93556d
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spelling	oai:doaj.org-article:ee235b33cb264e23897263c85e93556d2021-12-02T18:03:25ZFlow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening10.1038/s42004-021-00490-62399-3669https://doaj.org/article/ee235b33cb264e23897263c85e93556d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00490-6https://doaj.org/toc/2399-3669Flow reactors have applications in reaction screening and optimisation, but typically operate in linear or radial configurations. Here a bench-top parallel flow synthesiser which distributes reagents between sixteen microreactors allows for rapid optimisation of chemical libraries, with uniform flow distribution even when clogging occurs.Gwang-Noh AhnBrijesh M. SharmaSantosh LahoreSe-Jun YimShinde VidyacharanDong-Pyo KimNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Gwang-Noh Ahn Brijesh M. Sharma Santosh Lahore Se-Jun Yim Shinde Vidyacharan Dong-Pyo Kim Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
description	Flow reactors have applications in reaction screening and optimisation, but typically operate in linear or radial configurations. Here a bench-top parallel flow synthesiser which distributes reagents between sixteen microreactors allows for rapid optimisation of chemical libraries, with uniform flow distribution even when clogging occurs.
format	article
author	Gwang-Noh Ahn Brijesh M. Sharma Santosh Lahore Se-Jun Yim Shinde Vidyacharan Dong-Pyo Kim
author_facet	Gwang-Noh Ahn Brijesh M. Sharma Santosh Lahore Se-Jun Yim Shinde Vidyacharan Dong-Pyo Kim
author_sort	Gwang-Noh Ahn
title	Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
title_short	Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
title_full	Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
title_fullStr	Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
title_full_unstemmed	Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
title_sort	flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee235b33cb264e23897263c85e93556d
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Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening

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