The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan

Abstract Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients. However, the association between activin A and albuminuria remains unclear. We aim...

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Autores principales:	Shih-Chen Chang, Chien-Yi Hsu, Li-Kuo Liu, Ya-Wen Lu, Yi-Lin Tsai, Ruey-Hsing Chou, Po-Hsun Huang, Liang-Kung Chen, Shing-Jong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ee2528c65fd847aaa7b6f76f1ad0b667
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spelling	oai:doaj.org-article:ee2528c65fd847aaa7b6f76f1ad0b6672021-12-02T19:16:14ZThe association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan10.1038/s41598-021-99081-72045-2322https://doaj.org/article/ee2528c65fd847aaa7b6f76f1ad0b6672021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99081-7https://doaj.org/toc/2045-2322Abstract Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients. However, the association between activin A and albuminuria remains unclear. We aimed to evaluate their association by using cross-sectional data from community-dwelling middle-aged and older adults in Taiwan. We assessed 466 participants (67% male; mean age 71 ± 13 years) from the I-Lan Longitudinal Aging study for whom data pertaining to serum activin A level and urine albumin-to-creatinine ratio (UACR) were available. Of these, 323 (69%) had normal albuminuria, 123 (26%) had microalbuminuria, and 20 (4%) had overt albuminuria. Patients with overt albuminuria and microalbuminuria had significantly higher activin A concentrations than those in the normal albuminuria group (p < 0.001). Circulating activin A was significantly correlated with multiple risk factors, including higher systolic blood pressure and higher UACR. Univariate and multivariate results indicated that activin A level was an independent variable for albuminuria. The cutoff value of 602 pg/mL of activin A demonstrated a sensitivity of 70.6% and specificity of 75.7% (AUC 0.774) in diagnosing overt albuminuria. In conclusion, middle-aged and older adults with elevated activin A levels were associated with a higher incidence of albuminuria.Shih-Chen ChangChien-Yi HsuLi-Kuo LiuYa-Wen LuYi-Lin TsaiRuey-Hsing ChouPo-Hsun HuangLiang-Kung ChenShing-Jong LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shih-Chen Chang Chien-Yi Hsu Li-Kuo Liu Ya-Wen Lu Yi-Lin Tsai Ruey-Hsing Chou Po-Hsun Huang Liang-Kung Chen Shing-Jong Lin The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
description	Abstract Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients. However, the association between activin A and albuminuria remains unclear. We aimed to evaluate their association by using cross-sectional data from community-dwelling middle-aged and older adults in Taiwan. We assessed 466 participants (67% male; mean age 71 ± 13 years) from the I-Lan Longitudinal Aging study for whom data pertaining to serum activin A level and urine albumin-to-creatinine ratio (UACR) were available. Of these, 323 (69%) had normal albuminuria, 123 (26%) had microalbuminuria, and 20 (4%) had overt albuminuria. Patients with overt albuminuria and microalbuminuria had significantly higher activin A concentrations than those in the normal albuminuria group (p < 0.001). Circulating activin A was significantly correlated with multiple risk factors, including higher systolic blood pressure and higher UACR. Univariate and multivariate results indicated that activin A level was an independent variable for albuminuria. The cutoff value of 602 pg/mL of activin A demonstrated a sensitivity of 70.6% and specificity of 75.7% (AUC 0.774) in diagnosing overt albuminuria. In conclusion, middle-aged and older adults with elevated activin A levels were associated with a higher incidence of albuminuria.
format	article
author	Shih-Chen Chang Chien-Yi Hsu Li-Kuo Liu Ya-Wen Lu Yi-Lin Tsai Ruey-Hsing Chou Po-Hsun Huang Liang-Kung Chen Shing-Jong Lin
author_facet	Shih-Chen Chang Chien-Yi Hsu Li-Kuo Liu Ya-Wen Lu Yi-Lin Tsai Ruey-Hsing Chou Po-Hsun Huang Liang-Kung Chen Shing-Jong Lin
author_sort	Shih-Chen Chang
title	The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
title_short	The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
title_full	The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
title_fullStr	The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
title_full_unstemmed	The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
title_sort	association between serum activin a levels and albuminuria among community-dwelling middle-aged and older adults in taiwan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ee2528c65fd847aaa7b6f76f1ad0b667
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The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan

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