Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia

Yunchen Luo,1 Rekha Bajoria,2 Yongrong Lai,3 Hongfei Pan,4 Qiaochuan Li,3 Zhongming Zhang,3 Pijian Yang,5 Ratna Chatterjee,2 Yuzhen Liang11Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Re...

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Autores principales:	Luo Y, Bajoria R, Lai Y, Pan H, Li Q, Zhang Z, Yang P, Chatterjee R, Liang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	glucose homeostasis Non-transfusion-dependent thalassemia liver iron overload post prandial hyperglycaemia Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ee28dbf3202e432684dfe707497599bd
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spelling	oai:doaj.org-article:ee28dbf3202e432684dfe707497599bd2021-12-02T06:01:59ZPrevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia1178-7007https://doaj.org/article/ee28dbf3202e432684dfe707497599bd2019-04-01T00:00:00Zhttps://www.dovepress.com/prevalence-of-abnormal-glucose-homeostasis-in-chinese-patients-with-no-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yunchen Luo,1 Rekha Bajoria,2 Yongrong Lai,3 Hongfei Pan,4 Qiaochuan Li,3 Zhongming Zhang,3 Pijian Yang,5 Ratna Chatterjee,2 Yuzhen Liang11Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Reproductive Medicine, Institute for Women’s Health, Haematology Unit, University College Hospitals and Royal Free Hospital, London, UK; 3Department of Haematology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 4Department of Paediatrics, Affiliated Hospital of Youjiang Medical College for Nationality, Nanning, Guangxi, People’s Republic of China; 5Department of Geriatric Endocrinology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of ChinaPurpose: To determine the prevalence and underlying pathology of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia (NTDT).Patients and methods: In this study, we enrolled 211 patients aged 4–63 years with NTDT, including 79 β thalassemia intermedia patients, 114 Hb H disease patients and 18 Hb E/β thalassemia patients. All had oral glucose tolerance test, serum ferritin (SF), homeostasis model assessment (HOMA) and liver iron concentration (LIC) measurement. One hundred and twenty healthy age-matched controls were also used for the comparative purpose. Iron load was assessed by using SF and hepatic load by LIC using validated MRI techniques.Results: The 211 patients were divided into three groups according to their fasting and 2 hrs postprandial blood glucose levels: hypoglycemic, normal glucose tolerance (NGT) and hyperglycemic groups. In this study, 149 patients had NGT, 33 had hypoglycemia, 4 had diabetes and 25 had impaired glucose tolerance (IGT). None had impaired fasting glucose. There was a significant correlation between 2 hrs postprandial blood glucose levels and age, PINS120, HOMA-IR, alanine aminotransferase and LIC (P<0.05). Risk factors for IGT in NTDT patients were older age (≥24 years) and SF concentration of ≥2,500 ng/mL.Conclusion: Age ≥24 years and SF ≥2,500 ng/mL of NTDT patients were at a greater risk for impaired glucose tolerance.Keywords: glucose homeostasis, non-transfusion-dependent thalassemia, liver iron overload, post prandial hyperglycaemiaLuo YBajoria RLai YPan HLi QZhang ZYang PChatterjee RLiang YDove Medical Pressarticleglucose homeostasisNon-transfusion-dependent thalassemialiver iron overloadpost prandial hyperglycaemiaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 457-468 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	glucose homeostasis Non-transfusion-dependent thalassemia liver iron overload post prandial hyperglycaemia Specialties of internal medicine RC581-951
spellingShingle	glucose homeostasis Non-transfusion-dependent thalassemia liver iron overload post prandial hyperglycaemia Specialties of internal medicine RC581-951 Luo Y Bajoria R Lai Y Pan H Li Q Zhang Z Yang P Chatterjee R Liang Y Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia
description	Yunchen Luo,1 Rekha Bajoria,2 Yongrong Lai,3 Hongfei Pan,4 Qiaochuan Li,3 Zhongming Zhang,3 Pijian Yang,5 Ratna Chatterjee,2 Yuzhen Liang11Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Reproductive Medicine, Institute for Women’s Health, Haematology Unit, University College Hospitals and Royal Free Hospital, London, UK; 3Department of Haematology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 4Department of Paediatrics, Affiliated Hospital of Youjiang Medical College for Nationality, Nanning, Guangxi, People’s Republic of China; 5Department of Geriatric Endocrinology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of ChinaPurpose: To determine the prevalence and underlying pathology of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia (NTDT).Patients and methods: In this study, we enrolled 211 patients aged 4–63 years with NTDT, including 79 β thalassemia intermedia patients, 114 Hb H disease patients and 18 Hb E/β thalassemia patients. All had oral glucose tolerance test, serum ferritin (SF), homeostasis model assessment (HOMA) and liver iron concentration (LIC) measurement. One hundred and twenty healthy age-matched controls were also used for the comparative purpose. Iron load was assessed by using SF and hepatic load by LIC using validated MRI techniques.Results: The 211 patients were divided into three groups according to their fasting and 2 hrs postprandial blood glucose levels: hypoglycemic, normal glucose tolerance (NGT) and hyperglycemic groups. In this study, 149 patients had NGT, 33 had hypoglycemia, 4 had diabetes and 25 had impaired glucose tolerance (IGT). None had impaired fasting glucose. There was a significant correlation between 2 hrs postprandial blood glucose levels and age, PINS120, HOMA-IR, alanine aminotransferase and LIC (P<0.05). Risk factors for IGT in NTDT patients were older age (≥24 years) and SF concentration of ≥2,500 ng/mL.Conclusion: Age ≥24 years and SF ≥2,500 ng/mL of NTDT patients were at a greater risk for impaired glucose tolerance.Keywords: glucose homeostasis, non-transfusion-dependent thalassemia, liver iron overload, post prandial hyperglycaemia
format	article
author	Luo Y Bajoria R Lai Y Pan H Li Q Zhang Z Yang P Chatterjee R Liang Y
author_facet	Luo Y Bajoria R Lai Y Pan H Li Q Zhang Z Yang P Chatterjee R Liang Y
author_sort	Luo Y
title	Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia
title_short	Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia
title_full	Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia
title_fullStr	Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia
title_full_unstemmed	Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia
title_sort	prevalence of abnormal glucose homeostasis in chinese patients with non-transfusion-dependent thalassemia
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ee28dbf3202e432684dfe707497599bd
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Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia

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