A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery

A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery

Iatrogenic injury of the ureters is a feared complication of laparoscopic abdominal surgery. Here the authors present the NIR fluorophore ZW800-1 as an intraoperative imaging agent for ureter mapping, showing its safety, pharmacokinetic properties, and efficacy in healthy volunteers and patients und...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kim S. de Valk, Henricus J. Handgraaf, Marion M. Deken, Babs G. Sibinga Mulder, Adrianus R. Valentijn, Anton G. Terwisscha van Scheltinga, Joeri Kuil, Michiel J. van Esdonk, Jaap Vuijk, Rob F. Bevers, Koen C. Peeters, Fabian A. Holman, John V. Frangioni, Jacobus Burggraaf, Alexander L. Vahrmeijer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ee290759ae054fec9dc8492256ab1fea
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:ee290759ae054fec9dc8492256ab1fea
record_format dspace
spelling oai:doaj.org-article:ee290759ae054fec9dc8492256ab1fea2021-12-02T16:57:52ZA zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery10.1038/s41467-019-11014-12041-1723https://doaj.org/article/ee290759ae054fec9dc8492256ab1fea2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11014-1https://doaj.org/toc/2041-1723Iatrogenic injury of the ureters is a feared complication of laparoscopic abdominal surgery. Here the authors present the NIR fluorophore ZW800-1 as an intraoperative imaging agent for ureter mapping, showing its safety, pharmacokinetic properties, and efficacy in healthy volunteers and patients undergoing abdominopelvic surgery.Kim S. de ValkHenricus J. HandgraafMarion M. DekenBabs G. Sibinga MulderAdrianus R. ValentijnAnton G. Terwisscha van ScheltingaJoeri KuilMichiel J. van EsdonkJaap VuijkRob F. BeversKoen C. PeetersFabian A. HolmanJohn V. FrangioniJacobus BurggraafAlexander L. VahrmeijerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kim S. de Valk
Henricus J. Handgraaf
Marion M. Deken
Babs G. Sibinga Mulder
Adrianus R. Valentijn
Anton G. Terwisscha van Scheltinga
Joeri Kuil
Michiel J. van Esdonk
Jaap Vuijk
Rob F. Bevers
Koen C. Peeters
Fabian A. Holman
John V. Frangioni
Jacobus Burggraaf
Alexander L. Vahrmeijer
A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery
description Iatrogenic injury of the ureters is a feared complication of laparoscopic abdominal surgery. Here the authors present the NIR fluorophore ZW800-1 as an intraoperative imaging agent for ureter mapping, showing its safety, pharmacokinetic properties, and efficacy in healthy volunteers and patients undergoing abdominopelvic surgery.
format article
author Kim S. de Valk
Henricus J. Handgraaf
Marion M. Deken
Babs G. Sibinga Mulder
Adrianus R. Valentijn
Anton G. Terwisscha van Scheltinga
Joeri Kuil
Michiel J. van Esdonk
Jaap Vuijk
Rob F. Bevers
Koen C. Peeters
Fabian A. Holman
John V. Frangioni
Jacobus Burggraaf
Alexander L. Vahrmeijer
author_facet Kim S. de Valk
Henricus J. Handgraaf
Marion M. Deken
Babs G. Sibinga Mulder
Adrianus R. Valentijn
Anton G. Terwisscha van Scheltinga
Joeri Kuil
Michiel J. van Esdonk
Jaap Vuijk
Rob F. Bevers
Koen C. Peeters
Fabian A. Holman
John V. Frangioni
Jacobus Burggraaf
Alexander L. Vahrmeijer
author_sort Kim S. de Valk
title A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery
title_short A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery
title_full A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery
title_fullStr A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery
title_full_unstemmed A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery
title_sort zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/ee290759ae054fec9dc8492256ab1fea
work_keys_str_mv AT kimsdevalk azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT henricusjhandgraaf azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT marionmdeken azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT babsgsibingamulder azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT adrianusrvalentijn azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT antongterwisschavanscheltinga azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT joerikuil azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT michieljvanesdonk azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT jaapvuijk azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT robfbevers azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT koencpeeters azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT fabianaholman azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT johnvfrangioni azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT jacobusburggraaf azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT alexanderlvahrmeijer azwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT kimsdevalk zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT henricusjhandgraaf zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT marionmdeken zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT babsgsibingamulder zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT adrianusrvalentijn zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT antongterwisschavanscheltinga zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT joerikuil zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT michieljvanesdonk zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT jaapvuijk zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT robfbevers zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT koencpeeters zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT fabianaholman zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT johnvfrangioni zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT jacobusburggraaf zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
AT alexanderlvahrmeijer zwitterionicnearinfraredfluorophoreforrealtimeureteridentificationduringlaparoscopicabdominopelvicsurgery
_version_ 1718382481568169984

Ejemplares similares