CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID

A comprehensive comparative evaluation of the ability of L-17 compound (2-morpholino-5- phenyl-1,3,4-thiadiazine) and antioxidant lipoic acid (LA) to correct blood cytokine levels, metabolic disorders and morphological alterations in pancreas in alloxan-induced diabetes was performed for the first t...

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Autores principales:	I. G. Danilova, V. V. Emelianov, I. F. Gette, S. Yu. Medvedeva, T. S. Bulavintseva, M. V. Chereshneva, L. P. Sidorova, V. A. Chereshnev, K. V. Sokolova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	diabetes mellitus hyperglycemia inflammation insulin cytokines lipoic acid Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ee2997bbc10a4087862cc5ca84151671
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spelling	oai:doaj.org-article:ee2997bbc10a4087862cc5ca841516712021-11-18T08:03:46ZCYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID1563-06252313-741X10.15789/1563-0625-2018-1-35-44https://doaj.org/article/ee2997bbc10a4087862cc5ca841516712018-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1430https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XA comprehensive comparative evaluation of the ability of L-17 compound (2-morpholino-5- phenyl-1,3,4-thiadiazine) and antioxidant lipoic acid (LA) to correct blood cytokine levels, metabolic disorders and morphological alterations in pancreas in alloxan-induced diabetes was performed for the first time, using an experimental in vivo model. All the tested compounds have been found to correct hyperglycemia and decreased accumulation of glycated blood proteins. The tested L-17 compound belongs to the 1,3,4-thiadiazine series and is able to correct metabolic disorders occurring in alloxan-induced diabetes comparable to activity of LA antioxidant. However, L-17 reduces the cytokine levels to the values of intact animals, that preventing development of systemic inflammatory response which causes damage of target organs in diabetes mellitus.I. G. DanilovaV. V. EmelianovI. F. GetteS. Yu. MedvedevaT. S. BulavintsevaM. V. ChereshnevaL. P. SidorovaV. A. ChereshnevK. V. SokolovaSPb RAACIarticlediabetes mellitushyperglycemiainflammationinsulincytokineslipoic acidImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 1, Pp 35-44 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	diabetes mellitus hyperglycemia inflammation insulin cytokines lipoic acid Immunologic diseases. Allergy RC581-607
spellingShingle	diabetes mellitus hyperglycemia inflammation insulin cytokines lipoic acid Immunologic diseases. Allergy RC581-607 I. G. Danilova V. V. Emelianov I. F. Gette S. Yu. Medvedeva T. S. Bulavintseva M. V. Chereshneva L. P. Sidorova V. A. Chereshnev K. V. Sokolova CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
description	A comprehensive comparative evaluation of the ability of L-17 compound (2-morpholino-5- phenyl-1,3,4-thiadiazine) and antioxidant lipoic acid (LA) to correct blood cytokine levels, metabolic disorders and morphological alterations in pancreas in alloxan-induced diabetes was performed for the first time, using an experimental in vivo model. All the tested compounds have been found to correct hyperglycemia and decreased accumulation of glycated blood proteins. The tested L-17 compound belongs to the 1,3,4-thiadiazine series and is able to correct metabolic disorders occurring in alloxan-induced diabetes comparable to activity of LA antioxidant. However, L-17 reduces the cytokine levels to the values of intact animals, that preventing development of systemic inflammatory response which causes damage of target organs in diabetes mellitus.
format	article
author	I. G. Danilova V. V. Emelianov I. F. Gette S. Yu. Medvedeva T. S. Bulavintseva M. V. Chereshneva L. P. Sidorova V. A. Chereshnev K. V. Sokolova
author_facet	I. G. Danilova V. V. Emelianov I. F. Gette S. Yu. Medvedeva T. S. Bulavintseva M. V. Chereshneva L. P. Sidorova V. A. Chereshnev K. V. Sokolova
author_sort	I. G. Danilova
title	CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
title_short	CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
title_full	CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
title_fullStr	CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
title_full_unstemmed	CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
title_sort	cytokine regulation of regenerative processes in pancreatic gland in alloxan-induced diabetic rats, and it correction by 1,3,4-thiadiazine composition and lipoic acid
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/ee2997bbc10a4087862cc5ca84151671
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CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID

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