Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial

OBJECTIVE: Tonsillopharyngitis is one of the constituents of upper respiratory tract infection (URTI). Fever is a URTI symptom requiring treatment due to the occurrence of discomfort and high fever-based complications. This study primarily sets out to observe and compare the efficacy of intravenous...

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Autores principales:	Gizem Oncel, Atakan Yilmaz, Ramazan Sabirli, Yesim Kinaci Cimen, Mert Ozen, Murat Seyit, Ibrahim Turkcuer, Uzeyir Cimen
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	emergency department fever ibuprofen intravenous paracetamol upper respiratory tract infections Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/ee2bc3bc3b114899a1c18b83160fba24
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spelling	oai:doaj.org-article:ee2bc3bc3b114899a1c18b83160fba242021-11-12T11:16:11ZComparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial2452-247310.4103/2452-2473.329629https://doaj.org/article/ee2bc3bc3b114899a1c18b83160fba242021-01-01T00:00:00Zhttp://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2021;volume=21;issue=4;spage=177;epage=183;aulast=Oncelhttps://doaj.org/toc/2452-2473OBJECTIVE: Tonsillopharyngitis is one of the constituents of upper respiratory tract infection (URTI). Fever is a URTI symptom requiring treatment due to the occurrence of discomfort and high fever-based complications. This study primarily sets out to observe and compare the efficacy of intravenous administration of paracetamol and ibuprofen drugs on fever in adult patients with tonsillopharyngitis.METHODS: This study was performed in a prospective, randomized controlled, double-blind design. The study population was divided as Group 1 (treated with paracetamol) and as Group 2 (treated with ibuprofen). While the first group was treated with paracetamol as 1000 mg in 150 ml normal saline, the second group was treated with ibuprofen as 400 mg in 150 ml normal saline. The primary outcome was the decrease in fever at 15, 30, and 60 min, while the secondary outcome was the need for additional treatment after 60 min.RESULTS: One hundred and eighty-five patients were included in the final analysis. The mean age of the paracetamol group (57.4% male) was 28.36 ± 9.6, whereas that of the ibuprofen group (54.9% male) was 27.45 ± 7.98. Fever was reduced significantly between 0 and 60 min in both groups (P ≤ 0.001 and P ≤ 0.001, respectively). Although the antipyretic effect of ibuprofen was more pronounced in the early period than that of paracetamol, no significant difference was noted between the two groups in terms of fever drop between 0 and 60 min (P = 0.350).CONCLUSION: Although both drugs prove effective in controlling fever at the 60 min, stronger efficacy of ibuprofen in the first 15 min may enable rapid discharge from the emergency department.Gizem OncelAtakan YilmazRamazan SabirliYesim Kinaci CimenMert OzenMurat SeyitIbrahim TurkcuerUzeyir CimenWolters Kluwer Medknow Publicationsarticleemergency departmentfeveribuprofenintravenousparacetamolupper respiratory tract infectionsMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENTurkish Journal of Emergency Medicine, Vol 21, Iss 4, Pp 177-183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	emergency department fever ibuprofen intravenous paracetamol upper respiratory tract infections Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	emergency department fever ibuprofen intravenous paracetamol upper respiratory tract infections Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Gizem Oncel Atakan Yilmaz Ramazan Sabirli Yesim Kinaci Cimen Mert Ozen Murat Seyit Ibrahim Turkcuer Uzeyir Cimen Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial
description	OBJECTIVE: Tonsillopharyngitis is one of the constituents of upper respiratory tract infection (URTI). Fever is a URTI symptom requiring treatment due to the occurrence of discomfort and high fever-based complications. This study primarily sets out to observe and compare the efficacy of intravenous administration of paracetamol and ibuprofen drugs on fever in adult patients with tonsillopharyngitis.METHODS: This study was performed in a prospective, randomized controlled, double-blind design. The study population was divided as Group 1 (treated with paracetamol) and as Group 2 (treated with ibuprofen). While the first group was treated with paracetamol as 1000 mg in 150 ml normal saline, the second group was treated with ibuprofen as 400 mg in 150 ml normal saline. The primary outcome was the decrease in fever at 15, 30, and 60 min, while the secondary outcome was the need for additional treatment after 60 min.RESULTS: One hundred and eighty-five patients were included in the final analysis. The mean age of the paracetamol group (57.4% male) was 28.36 ± 9.6, whereas that of the ibuprofen group (54.9% male) was 27.45 ± 7.98. Fever was reduced significantly between 0 and 60 min in both groups (P ≤ 0.001 and P ≤ 0.001, respectively). Although the antipyretic effect of ibuprofen was more pronounced in the early period than that of paracetamol, no significant difference was noted between the two groups in terms of fever drop between 0 and 60 min (P = 0.350).CONCLUSION: Although both drugs prove effective in controlling fever at the 60 min, stronger efficacy of ibuprofen in the first 15 min may enable rapid discharge from the emergency department.
format	article
author	Gizem Oncel Atakan Yilmaz Ramazan Sabirli Yesim Kinaci Cimen Mert Ozen Murat Seyit Ibrahim Turkcuer Uzeyir Cimen
author_facet	Gizem Oncel Atakan Yilmaz Ramazan Sabirli Yesim Kinaci Cimen Mert Ozen Murat Seyit Ibrahim Turkcuer Uzeyir Cimen
author_sort	Gizem Oncel
title	Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial
title_short	Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial
title_full	Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial
title_fullStr	Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial
title_full_unstemmed	Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial
title_sort	comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: a prospective, randomized controlled, double-blind clinical trial
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/ee2bc3bc3b114899a1c18b83160fba24
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Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial

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